Table 1.
Distributions of open durations for wild-type α7 nAChR
[ACh]Calcium free1.8 mM Ca2+
Mean open, sWeightMean open, sWeight
1 µM 1.2 × 10−5 ± 1.7 × 10−6  1.0  1.5 × 10−5 ± 3.7 × 10−6 1.0 × 10−4 ± 9.7 × 10−6 0.67 ± 0.02 0.33 ± 0.02 
 n = 3  n = 6  
10 µM 1.0 × 10−5 ± 1.2 × 10−6 6.1 × 10−5 ± 6.4 × 10−6 0.90 ± 0.03 0.10 ± 0.06 1.1 × 10−5 ± 1.3 × 10−6 1.2 × 10−4 ± 3.4 × 10−5 0.58 ± 0.06 0.41 ± 0.06 
 n = 6  n = 4  n = 4 
100 µM 1.2 × 10−5 ± 1.6 × 10−6 8.9 × 10−5 ± 1.6 × 10−6 0.55 ± 0.03 0.45 ± 0.3 1.2 × 10−5 ± 1.7 × 10−6 9.5 × 10−5 ± 8.5 × 10−6 0.59 ± 0.04 0.41 ± 0.04 
 n = 6  n = 6  
[ACh]Calcium free1.8 mM Ca2+
Mean open, sWeightMean open, sWeight
1 µM 1.2 × 10−5 ± 1.7 × 10−6  1.0  1.5 × 10−5 ± 3.7 × 10−6 1.0 × 10−4 ± 9.7 × 10−6 0.67 ± 0.02 0.33 ± 0.02 
 n = 3  n = 6  
10 µM 1.0 × 10−5 ± 1.2 × 10−6 6.1 × 10−5 ± 6.4 × 10−6 0.90 ± 0.03 0.10 ± 0.06 1.1 × 10−5 ± 1.3 × 10−6 1.2 × 10−4 ± 3.4 × 10−5 0.58 ± 0.06 0.41 ± 0.06 
 n = 6  n = 4  n = 4 
100 µM 1.2 × 10−5 ± 1.6 × 10−6 8.9 × 10−5 ± 1.6 × 10−6 0.55 ± 0.03 0.45 ± 0.3 1.2 × 10−5 ± 1.7 × 10−6 9.5 × 10−5 ± 8.5 × 10−6 0.59 ± 0.04 0.41 ± 0.04 
 n = 6  n = 6  

Time constants and relative weights of exponential components were obtained by fitting open-duration histograms for n experiments.

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