Table 4.
Mean current density (pA/pF) of HCN1 WT and NA/DC mutant, in the presence and absence of TRIP8b (1a-4), from recordings obtained in cortical neurons derived from hiPSCs
V/mVHCN1 WTHCN1 WT + TRIP8bP valueHCN1 NA/DCHCN1 NA/DC + TRIP8bP value
−20 3.8 ± 1.1 0.4 ± 1.7 0.5 1.4 ± 0.5 1.8 ± 0.9 0.9 
−30 0.1 ± 0.8 −3.4 ± 2.2 1.9E−02 −0.5 ± 0.3 −1.2 ± 0.5 0.5 
−40 −2.9 ± 1.1 −6.9 ± 3.2 0.1 −1.8 ± 0.5 −3.8 ± 0.6 8E−02 
−50 −4.6 ± 1.5 −10.3 ± 4.2 8.6E−02 −3.2 ± 0.7 −6.0 ± 1.0 3.1E−02 
−60 −6.8 ± 1.9 −14.0 ± 5.2 4.9E−02 −5.3 ± 1.0 −8.3 ± 1.4 3.4E−02 
−70 −11.5 ± 2.7 −22.8 ± 6.2 3.9E−02 −8.6 ± 1.5 −12.3 ± 2.0 4.3E−02 
−80 −20.5 ± 5.8 −38.4 ± 8.9 3.5E−02 −13.7 ± 3.1 −22.4 ± 3.5 3.1E−02 
−90 −32.9 ± 9.7 −62.8 ± 13.5 2.0E−02 −19.5 ± 6.1 −38.1 ± 5.8 1.3E−02 
−100 −43.4 ± 13.5 −88.5 ± 19.1 8.3E−03 −25.4 ± 8.7 −53.2 ± 7.6 7.2E−03 
−110 −52.9 ± 17 −112 ± 23.9 4.0E−03 −30.5 ± 10.8 −66.7 ± 9.4 4.8E−03 
−120 −57.5 ± 16.3 −132.4 ± 28 2.4E−03 −36.2 ± 10.5 −79.0 ± 11.6 3.0E−03 
V/mVHCN1 WTHCN1 WT + TRIP8bP valueHCN1 NA/DCHCN1 NA/DC + TRIP8bP value
−20 3.8 ± 1.1 0.4 ± 1.7 0.5 1.4 ± 0.5 1.8 ± 0.9 0.9 
−30 0.1 ± 0.8 −3.4 ± 2.2 1.9E−02 −0.5 ± 0.3 −1.2 ± 0.5 0.5 
−40 −2.9 ± 1.1 −6.9 ± 3.2 0.1 −1.8 ± 0.5 −3.8 ± 0.6 8E−02 
−50 −4.6 ± 1.5 −10.3 ± 4.2 8.6E−02 −3.2 ± 0.7 −6.0 ± 1.0 3.1E−02 
−60 −6.8 ± 1.9 −14.0 ± 5.2 4.9E−02 −5.3 ± 1.0 −8.3 ± 1.4 3.4E−02 
−70 −11.5 ± 2.7 −22.8 ± 6.2 3.9E−02 −8.6 ± 1.5 −12.3 ± 2.0 4.3E−02 
−80 −20.5 ± 5.8 −38.4 ± 8.9 3.5E−02 −13.7 ± 3.1 −22.4 ± 3.5 3.1E−02 
−90 −32.9 ± 9.7 −62.8 ± 13.5 2.0E−02 −19.5 ± 6.1 −38.1 ± 5.8 1.3E−02 
−100 −43.4 ± 13.5 −88.5 ± 19.1 8.3E−03 −25.4 ± 8.7 −53.2 ± 7.6 7.2E−03 
−110 −52.9 ± 17 −112 ± 23.9 4.0E−03 −30.5 ± 10.8 −66.7 ± 9.4 4.8E−03 
−120 −57.5 ± 16.3 −132.4 ± 28 2.4E−03 −36.2 ± 10.5 −79.0 ± 11.6 3.0E−03 

Data are reported as mean ± SEM. Statistical analysis was performed with one-way ANOVA, followed by post-hoc Fisher test.

View Large
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal