Table 3.
Mean current density (pA/pF) of HCN1 WT and NA/DC mutant, in the presence and absence of TRIP8b (1a-4), from recordings obtained in cortical neurons from neonatal rats
V/mVHCN1 WTHCN1 WT + TRIP8bP valueHCN1 NA/DCHCN1 NA/DC + TRIP8bP value
−20 0.1 ± 0.3 0.1 ± 0.4 0.14 0.9 ± 1.0 0.7 ± 0.7 4.9E−02 
−30 −1.1 ± 0.4 −1.4 ± 0.8 1.4E−03 −0.3 ± 0.6 −0.7 ± 0.6 3.7E−03 
−40 −2.0 ± 0.5 −2.3 ± 1.1 2E−05 −0.9 ± 0.4 −1.5 ± 0.6 3.0E−03 
−50 −3.3 ± 0.8 −3.3 ± 1.3 2E−04 −1.4 ± 0.4 −2.4 ± 0.9 5.2E−04 
−60 −4.7 ± 1.2 −5.8 ± 2.1 6.4E−04 −2.0 ± 0.5 −4.4 ± 1.9 4.2E−05 
−70 −6.7 ± 2.0 −10.6 ± 2.9 1.8E−03 −3.0 ± 1.1 −9.1 ± 4.8 4.8E−05 
−80 −9.9 ± 2.9 −22.2 ± 5.2 2.3E−03 −6.8 ± 0.6 −18.7 ± 7.3 1.2E−05 
−90 −14.1 ± 4.2 −36.2 ± 9.9 3.2E−03 −12.4 ± 5.5 −32.0 ± 9.6 1.7E−05 
−100 −18.9 ± 5.5 −48.6 ± 13.7 3.7E−03 −16.3 ± 8.6 −42.2 ± 12.2 2.6E−05 
−110 −24.0 ± 7.1 −59.8 ± 16.4 3.1E−03 −19.6 ± 10.5 −52.3 ± 15.6 2.1E−05 
−120 −27.2 ± 7.7 −71.6 ± 19.6 6.2E−05 −22.5 ± 12.7 −62.4 ± 19.1 1.7E−05 
V/mVHCN1 WTHCN1 WT + TRIP8bP valueHCN1 NA/DCHCN1 NA/DC + TRIP8bP value
−20 0.1 ± 0.3 0.1 ± 0.4 0.14 0.9 ± 1.0 0.7 ± 0.7 4.9E−02 
−30 −1.1 ± 0.4 −1.4 ± 0.8 1.4E−03 −0.3 ± 0.6 −0.7 ± 0.6 3.7E−03 
−40 −2.0 ± 0.5 −2.3 ± 1.1 2E−05 −0.9 ± 0.4 −1.5 ± 0.6 3.0E−03 
−50 −3.3 ± 0.8 −3.3 ± 1.3 2E−04 −1.4 ± 0.4 −2.4 ± 0.9 5.2E−04 
−60 −4.7 ± 1.2 −5.8 ± 2.1 6.4E−04 −2.0 ± 0.5 −4.4 ± 1.9 4.2E−05 
−70 −6.7 ± 2.0 −10.6 ± 2.9 1.8E−03 −3.0 ± 1.1 −9.1 ± 4.8 4.8E−05 
−80 −9.9 ± 2.9 −22.2 ± 5.2 2.3E−03 −6.8 ± 0.6 −18.7 ± 7.3 1.2E−05 
−90 −14.1 ± 4.2 −36.2 ± 9.9 3.2E−03 −12.4 ± 5.5 −32.0 ± 9.6 1.7E−05 
−100 −18.9 ± 5.5 −48.6 ± 13.7 3.7E−03 −16.3 ± 8.6 −42.2 ± 12.2 2.6E−05 
−110 −24.0 ± 7.1 −59.8 ± 16.4 3.1E−03 −19.6 ± 10.5 −52.3 ± 15.6 2.1E−05 
−120 −27.2 ± 7.7 −71.6 ± 19.6 6.2E−05 −22.5 ± 12.7 −62.4 ± 19.1 1.7E−05 

Data are reported as mean ± SEM. Statistical analysis performed with one-way ANOVA, followed by post-hoc Fisher test.

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