| V/mV . | . | HCN1 WT . | HCN1 WT+ TRIP8b . | P value . | HCN1 NA/DC . | HCN1 NA/DC + TRIP8b . | P value . |
|---|---|---|---|---|---|---|---|
| −70 | τ activation (ms) | 540.5 ± 71.3 | 875.7 ± 135.3 | 4.1E−03 | 477.2 ± 33.1 | 476.2 ± 42.8 | 1.0 |
| −80 | 450.5 ± 74.4 | 721.1 ± 55.7 | 3.8E−03 | 386.6 ± 35.8 | 459.3 ± 46.7 | 0.4 | |
| −90 | 319.4 ± 46.3 | 516.4 ± 41.0 | 2.3E−03 | 299.6 ± 28.5 | 363.5 ± 34.2 | 0.25 | |
| −100 | 242.5 ± 28.9 | 364.0 ± 26.7 | 3.15E−03 | 238.8 ± 20.9 | 278.1 ± 21.0 | 0.3 | |
| −110 | 185.4 ± 18.4 | 305.6 ± 28.0 | 7.5E−03 | 201.4 ± 14.9 | 220.4 ± 13.0 | 0.4 | |
| −120 | 159.3 ± 13.2 | 257.6 ± 20.4 | 3.9E−03 | 177.9 ± 12.2 | 199.6 ± 21.6 | 0.4 | |
| −130 | 141.2 ± 11.4 | 221.9 ± 21.9 | 6.4E−04 | 153.5 ± 9.9 | 152.7 ± 11.2 | 1.0 | |
| −40 | τ deactivation (ms) | 117.7 ± 3.2 | 89.7 ± 6.2 | 7.7E−03 | 116.9 ± 8.7 | 120.8 ± 5.3 | 0.7 |
| V/mV . | . | HCN1 WT . | HCN1 WT+ TRIP8b . | P value . | HCN1 NA/DC . | HCN1 NA/DC + TRIP8b . | P value . |
|---|---|---|---|---|---|---|---|
| −70 | τ activation (ms) | 540.5 ± 71.3 | 875.7 ± 135.3 | 4.1E−03 | 477.2 ± 33.1 | 476.2 ± 42.8 | 1.0 |
| −80 | 450.5 ± 74.4 | 721.1 ± 55.7 | 3.8E−03 | 386.6 ± 35.8 | 459.3 ± 46.7 | 0.4 | |
| −90 | 319.4 ± 46.3 | 516.4 ± 41.0 | 2.3E−03 | 299.6 ± 28.5 | 363.5 ± 34.2 | 0.25 | |
| −100 | 242.5 ± 28.9 | 364.0 ± 26.7 | 3.15E−03 | 238.8 ± 20.9 | 278.1 ± 21.0 | 0.3 | |
| −110 | 185.4 ± 18.4 | 305.6 ± 28.0 | 7.5E−03 | 201.4 ± 14.9 | 220.4 ± 13.0 | 0.4 | |
| −120 | 159.3 ± 13.2 | 257.6 ± 20.4 | 3.9E−03 | 177.9 ± 12.2 | 199.6 ± 21.6 | 0.4 | |
| −130 | 141.2 ± 11.4 | 221.9 ± 21.9 | 6.4E−04 | 153.5 ± 9.9 | 152.7 ± 11.2 | 1.0 | |
| −40 | τ deactivation (ms) | 117.7 ± 3.2 | 89.7 ± 6.2 | 7.7E−03 | 116.9 ± 8.7 | 120.8 ± 5.3 | 0.7 |
Data are reported as mean ± SEM. Statistical analysis performed with one-way ANOVA, followed by post-hoc Tukey test.