Table 1.
Parameters for Scheme 1, fitted with data at 0 µM NS11021
ParameterFit AFit B
J0 0.08 0.06 
KD (µM) 41 17 
L0 2.8 × 10−6 1.0 × 10−5 
zJ (e0) 0.30 0.41 
zL (e0) 0.57 0.58 
C 2.5 17 
D 29 16 
E 20 1.1 
ParameterFit AFit B
J0 0.08 0.06 
KD (µM) 41 17 
L0 2.8 × 10−6 1.0 × 10−5 
zJ (e0) 0.30 0.41 
zL (e0) 0.57 0.58 
C 2.5 17 
D 29 16 
E 20 1.1 

Simultaneous (global) fitting was performed using G–V relations over a range of Ca2+ with 0 µM NS11021, as described in Materials and methods. G–V relations predicted by above parameters in Fit A and Fit B can be found in Figs. 7 A and 8 A, respectively. χ2 values for comparison of experimental data versus corresponding prediction (based on 90 experimental data points): Fit A, 0.045; Fit B, 0.044.

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