| Rise time (ms) | τFast (ms) | τSlow (ms) | % τFast | Weighted τ (ms) | % Desensitization | Amplitude (peak, pA/pF) | n | |
|---|---|---|---|---|---|---|---|---|
| GluN2A WT | 5.7 ± 0.3 | 24 ± 2 | 180 ± 22 | 84 ± 3 | 46 ± 6 | 54 ± 5 | 190 ± 22 | 25 |
| GluN2A-L550A | 6.4 ± 0.8 | 11 ± 0.7 | 66 ± 24 | 93 ± 3 | 13 ± 0.4 | 30 ± 3 | 28 ± 2.6 | 12 |
| GluN2A-E551A | 5.8 ± 0.4 | 26 ± 3 | 220 ± 34 | 86 ± 3 | 48 ± 6 | 54 ± 5 | 220 ± 52 | 16 |
| GluN2A-P552A | 4.3 ± 0.3 | 16 ± 2 | 170 ± 15 | 87 ± 4 | 32 ± 4 | 31 ± 5 | 160 ± 14 | 12 |
| GluN2A-F553A | 5.9 ± 1 | 64 ± 16 | 790 ± 160 | 43 ± 6 | 420 ± 55a | 18 ± 2 | 12 ± 1.5 | 9 |
| GluN2A-A555P | 6.8 ± 0.7 | 24 ± 2 | 190 ± 18 | 87 ± 4 | 46 ± 18 | 74 ± 7 | 170 ± 24 | 13 |
| GluN2A-F553Y | 5.5 ± 0.7 | 25 ± 2 | 230 ± 75 | 94 ± 2 | 37 ± 6 | 64 ± 5 | 79 ± 11 | 12 |
| Rise time (ms) | τ | τ | % τ | Weighted τ (ms) | % Desensitization | Amplitude (peak, pA/pF) | ||
|---|---|---|---|---|---|---|---|---|
| GluN2A WT | 5.7 ± 0.3 | 24 ± 2 | 180 ± 22 | 84 ± 3 | 46 ± 6 | 54 ± 5 | 190 ± 22 | 25 |
| GluN2A-L550A | 6.4 ± 0.8 | 11 ± 0.7 | 66 ± 24 | 93 ± 3 | 13 ± 0.4 | 30 ± 3 | 28 ± 2.6 | 12 |
| GluN2A-E551A | 5.8 ± 0.4 | 26 ± 3 | 220 ± 34 | 86 ± 3 | 48 ± 6 | 54 ± 5 | 220 ± 52 | 16 |
| GluN2A-P552A | 4.3 ± 0.3 | 16 ± 2 | 170 ± 15 | 87 ± 4 | 32 ± 4 | 31 ± 5 | 160 ± 14 | 12 |
| GluN2A-F553A | 5.9 ± 1 | 64 ± 16 | 790 ± 160 | 43 ± 6 | 420 ± 55 | 18 ± 2 | 12 ± 1.5 | 9 |
| GluN2A-A555P | 6.8 ± 0.7 | 24 ± 2 | 190 ± 18 | 87 ± 4 | 46 ± 18 | 74 ± 7 | 170 ± 24 | 13 |
| GluN2A-F553Y | 5.5 ± 0.7 | 25 ± 2 | 230 ± 75 | 94 ± 2 | 37 ± 6 | 64 ± 5 | 79 ± 11 | 12 |
All data are from GluN1 co-expressed with GluN2A. Data are expressed as mean ± SEM to two significant figures.
P < 0.05 compared with WT GluN2A, one-way ANOVA, Tukey’s post hoc test. Analysis performed on rise time and weighted τ, and corrected for familywise error.