Table 2.
Summary of deactivation time course for GluN2A mutations
Rise time (ms)τFast (ms)τSlow (ms)% τFastWeighted τ (ms)% DesensitizationAmplitude (peak, pA/pF)n
GluN2A WT 5.7 ± 0.3 24 ± 2 180 ± 22 84 ± 3 46 ± 6 54 ± 5 190 ± 22 25 
GluN2A-L550A 6.4 ± 0.8 11 ± 0.7 66 ± 24 93 ± 3 13 ± 0.4 30 ± 3 28 ± 2.6 12 
GluN2A-E551A 5.8 ± 0.4 26 ± 3 220 ± 34 86 ± 3 48 ± 6 54 ± 5 220 ± 52 16 
GluN2A-P552A 4.3 ± 0.3 16 ± 2 170 ± 15 87 ± 4 32 ± 4 31 ± 5 160 ± 14 12 
GluN2A-F553A 5.9 ± 1 64 ± 16 790 ± 160 43 ± 6 420 ± 55a 18 ± 2 12 ± 1.5 9 
GluN2A-A555P 6.8 ± 0.7 24 ± 2 190 ± 18 87 ± 4 46 ± 18 74 ± 7 170 ± 24 13 
GluN2A-F553Y 5.5 ± 0.7 25 ± 2 230 ± 75 94 ± 2 37 ± 6 64 ± 5 79 ± 11 12 

All data are from GluN1 co-expressed with GluN2A. Data are expressed as mean ± SEM to two significant figures.

a

P < 0.05 compared with WT GluN2A, one-way ANOVA, Tukey’s post hoc test. Analysis performed on rise time and weighted τ, and corrected for familywise error.

[ViewLarge]
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal