Table 1. Summary of steady-state... | Rockefeller University Press

Table 1.

Summary of steady-state inactivation properties

Na_V1.5 (Control or CaM overexpressed)	V_1/2 inactivation	k	n
WT	−83.2 ± 1.2	4.9 ± 0.1	26
+ CaM	−84.7 ± 1.8	4.8 ± 0.1	14
K1493A	−80.4 ± 1.5	4.6 ± 0.1	9
+ CaM	−82.1 ± 6.6	4.4 ± 0.3	5
K1493E	−88.7 ± 0.7^a	5.0 ± 0.1	31
+ CaM	−88.5 ± 0.8^a	5.1 ± 0.1	8
E1784K	−91.5 ± 0.9^a	6.6 ± 0.2	18
+ CaM	−88.6 ± 1.1^a	6.1 ± 0.1	6
K1493A+E1784K	−84.7 ± 2.3^b	6.0 ± 0.2	10
+ CaM	−85.8 ± 2.0^b	6.3 ± 0.2	5
K1493E+E1784K	−87.6 ± 0.8^a^{^,}^b	6.2 ± 0.1	27
+ CaM	−87.4 ± 0.8^a^{^,}^b	5.9 ± 0.1	14
K1505N	−87.6 ± 1.4^a	4.8 ± 0.2	9
+ CaM	−89.3 ± 2.3^a	5.0 ± 0.1	8
K1505E	−90.8 ± 1.5^a	5.1 ± 0.2	9
+ CaM	−87.5 ± 1.3^a	5.3 ± 0.2	8
K1493I	−82.4 ± 1.8^b	4.7 ± 0.1	7
K1493I+E1784K	−82.9 ± 2.6^b	5.3 ± 0.1	7
K1492E	−81.7 ± 1.4	4.3 ± 0.1	10
K1492E+E1784K	−87.5 ± 1.8	5.7 ± 0.2	19

Na_V1.5 (Control or CaM overexpressed)	V_1/2 inactivation	k	n
WT	−83.2 ± 1.2	4.9 ± 0.1	26
+ CaM	−84.7 ± 1.8	4.8 ± 0.1	14
K1493A	−80.4 ± 1.5	4.6 ± 0.1	9
+ CaM	−82.1 ± 6.6	4.4 ± 0.3	5
K1493E	−88.7 ± 0.7^a	5.0 ± 0.1	31
+ CaM	−88.5 ± 0.8^a	5.1 ± 0.1	8
E1784K	−91.5 ± 0.9^a	6.6 ± 0.2	18
+ CaM	−88.6 ± 1.1^a	6.1 ± 0.1	6
K1493A+E1784K	−84.7 ± 2.3^b	6.0 ± 0.2	10
+ CaM	−85.8 ± 2.0^b	6.3 ± 0.2	5
K1493E+E1784K	−87.6 ± 0.8^a^{^,}^b	6.2 ± 0.1	27
+ CaM	−87.4 ± 0.8^a^{^,}^b	5.9 ± 0.1	14
K1505N	−87.6 ± 1.4^a	4.8 ± 0.2	9
+ CaM	−89.3 ± 2.3^a	5.0 ± 0.1	8
K1505E	−90.8 ± 1.5^a	5.1 ± 0.2	9
+ CaM	−87.5 ± 1.3^a	5.3 ± 0.2	8
K1493I	−82.4 ± 1.8^b	4.7 ± 0.1	7
K1493I+E1784K	−82.9 ± 2.6^b	5.3 ± 0.1	7
K1492E	−81.7 ± 1.4	4.3 ± 0.1	10
K1492E+E1784K	−87.5 ± 1.8	5.7 ± 0.2	19

Data presented as mean ± SEM.

^aP < 0.05 compared to WT.

^bP < 0.05 compared to E1784K.