Table 4. Effect of apamin on... | Rockefeller University Press

Table 4.

Effect of apamin on charbachol-induced CA2 PN spontaneous activity

Measurement	Control (n = 25)	SK channels blocked (0.1 µM apamin; n = 10)	Statistics
ACSF-V_M (mV)	−75 ± 1.2	−75 ± 2.2	P = 0.95^a
CCh-V_M (mV)	−64 ± 1.0	−66 ± 2.3	P = 0.49^a
Δ_ACSF-CCh V_M (mV)	11 ± 1.0	9.1 ± 1.3	P = 0.55^b
Depolarization rate (mV/min)	6.5 ± 0.8	5.3 ± 1.6	P = 0.50^a
Burst onset (min)	6.4 ± 0.7	6.5 ± 1.3	P = 0.93^a
Interburst interval (s)	100 ± 14.7	120 ± 31.2	P = 0.58^a
Burst-V_M (mV)	−42 ± 1.0	−42 ± 1.2	P = 0.41^a
Interburst-V_M (mV)	−62 ± 0.8	−59 ± 1.3	P = 0.035^a
Δ_burst-IBI V_M (mV)	21 ± 1.2	17 ± 1.9	P = 0.045^a
Burst rise rate (mV/s)	3.5 ± 0.5	5.6 ± 1.2	P = 0.06^b
Burst decay rate (mV/s)	−4.6 ± 0.8	−4.7 ± 1.0	P = 0.91^b
Burst duration (s)	3.8 ± 0.5	5.4 ± 1.9	P = 0.97^b
Number of APs/burst	22 ± 2.5	16 ± 2.0	P = 0.20^b
Firing frequency in burst (Hz)	13 ± 1.9	12 ± 3.0	P = 0.94^b

Measurement	Control (n = 25)	SK channels blocked (0.1 µM apamin; n = 10)	Statistics
ACSF-V_M (mV)	−75 ± 1.2	−75 ± 2.2	P = 0.95^a
CCh-V_M (mV)	−64 ± 1.0	−66 ± 2.3	P = 0.49^a
Δ_ACSF-CCh V_M (mV)	11 ± 1.0	9.1 ± 1.3	P = 0.55^b
Depolarization rate (mV/min)	6.5 ± 0.8	5.3 ± 1.6	P = 0.50^a
Burst onset (min)	6.4 ± 0.7	6.5 ± 1.3	P = 0.93^a
Interburst interval (s)	100 ± 14.7	120 ± 31.2	P = 0.58^a
Burst-V_M (mV)	−42 ± 1.0	−42 ± 1.2	P = 0.41^a
Interburst-V_M (mV)	−62 ± 0.8	−59 ± 1.3	P = 0.035^a
Δ_burst-IBI V_M (mV)	21 ± 1.2	17 ± 1.9	P = 0.045^a
Burst rise rate (mV/s)	3.5 ± 0.5	5.6 ± 1.2	P = 0.06^b
Burst decay rate (mV/s)	−4.6 ± 0.8	−4.7 ± 1.0	P = 0.91^b
Burst duration (s)	3.8 ± 0.5	5.4 ± 1.9	P = 0.97^b
Number of APs/burst	22 ± 2.5	16 ± 2.0	P = 0.20^b
Firing frequency in burst (Hz)	13 ± 1.9	12 ± 3.0	P = 0.94^b

t test.

Mann–Whitney U test.