Table 3. Effect of TTA-A2 on... | Rockefeller University Press

Table 3.

Effect of TTA-A2 on charbachol-induced CA2 PN spontaneous activity

Measurement	Control (n = 25)	T-type voltage-gated calcium channels blocked (2 µM TTA-A2; n = 9)	Statistics
ACSF-V_M (mV)	−75 ± 1.2	−72 ± 2.3	P = 0.28^a
CCh-V_M (mV)	−64 ± 1.0	−62 ± 1.8	P = 0.22^a
Δ_ACSF-CCh V_M (mV)	11 ± 1.0	11 ± 1.0	P = 0.89^b
Depolarization rate (mV/min)	6.5 ± 0.8	4.6 ± 0.9	P = 0.12^a
Burst onset (min)	6.4 ± 0.7	6.0 ± 1.0	P = 0.78^a
Interburst interval (s)	100 ± 14.7	109 ± 18.4	P = 0.74^a
Burst-V_M (mV)	−42 ± 1.0	−42 ± 0.7	P = 0.74^b
Interburst-V_M (mV)	−62 ± 0.8	−60 ± 1.2	P = 0.17^a
Δ_burst-IBI V_M (mV)	21 ± 1.2	18 ± 0.9	P = 0.13^b
Burst rise rate (mV/s)	3.5 ± 0.5	2.8 ± 0.5	P = 0.69^b
Burst decay rate (mV/s)	−4.6 ± 0.8	−5.1 ± 1.1	P = 0.83^b
Burst duration (s)	3.8 ± 0.5	8.9 ± 1.9	P = 0.006^b
Number of APs/burst	22 ± 2.5	31 ± 6.4	P = 0.072^b
Firing frequency in burst (Hz)	13 ± 1.9	10 ± 1.9	P = 0.66^b

Measurement	Control (n = 25)	T-type voltage-gated calcium channels blocked (2 µM TTA-A2; n = 9)	Statistics
ACSF-V_M (mV)	−75 ± 1.2	−72 ± 2.3	P = 0.28^a
CCh-V_M (mV)	−64 ± 1.0	−62 ± 1.8	P = 0.22^a
Δ_ACSF-CCh V_M (mV)	11 ± 1.0	11 ± 1.0	P = 0.89^b
Depolarization rate (mV/min)	6.5 ± 0.8	4.6 ± 0.9	P = 0.12^a
Burst onset (min)	6.4 ± 0.7	6.0 ± 1.0	P = 0.78^a
Interburst interval (s)	100 ± 14.7	109 ± 18.4	P = 0.74^a
Burst-V_M (mV)	−42 ± 1.0	−42 ± 0.7	P = 0.74^b
Interburst-V_M (mV)	−62 ± 0.8	−60 ± 1.2	P = 0.17^a
Δ_burst-IBI V_M (mV)	21 ± 1.2	18 ± 0.9	P = 0.13^b
Burst rise rate (mV/s)	3.5 ± 0.5	2.8 ± 0.5	P = 0.69^b
Burst decay rate (mV/s)	−4.6 ± 0.8	−5.1 ± 1.1	P = 0.83^b
Burst duration (s)	3.8 ± 0.5	8.9 ± 1.9	P = 0.006^b
Number of APs/burst	22 ± 2.5	31 ± 6.4	P = 0.072^b
Firing frequency in burst (Hz)	13 ± 1.9	10 ± 1.9	P = 0.66^b

t test.

Mann–Whitney U test.