| Measurement . | Control (n = 25) . | Nonselective block of voltage-gated potassium channels (100 µM 4-AP; n = 8) . | D-type potassium channels blocked (100 nM ⍺-DTX; n = 9) . | Statistics . |
|---|---|---|---|---|
| ACSF-VM (mV) | −75 ± 1.2 | −76 ± 1.5 | −71 ± 1.1 | P = 0.152a |
| CCh-VM (mV) | −64 ± 1.0 | −66 ± 1.5 | −65 ± 0.7 | P = 0.613 |
| ΔACSF-CCh VM (mV) | 11 ± 1.0 | 10 ± 1.5 | 7 ± 0.9 | P = 0.058 |
| Depolarization rate (mV/min) | 6.5 ± 0.8 | 5.4 ± 0.8 | 3.4 ± 0.6 | P = 0.091 |
| Burst onset (min) | 6.4 ± 0.7 | 4.4 ± 1.0 | 6.1 ± 0.9 | P = 0.078a |
| Interburst interval (s) | 100 ± 14.7 | 119 ± 26.2 | 136 ± 33.0 | P = 0.512a |
| Burst-VM (mV) | −42 ± 1.0 | −37 ± 3.2 | −44 ± 0.9 | P = 0.067 |
| Interburst-VM (mV) | −62 ± 0.8 | −66 ± 1.5 | −64 ± 1.2 | P = 0.079a |
| Δburst-IBI VM (mV) | 22 ± 1.3 | 29 ± 3.2b | 20 ± 1.8 | P = 0.034a |
| Burst rise rate (mV/s) | 3.5 ± 0.5 | 97.5 ± 38.0c | 65.6 ± 33.4c | P < 0.001 |
| Burst decay rate (mV/s) | −4.6 ± 0.8 | −21.6 ± 5.0c | −13.3 ± 6.5 | P = 0.008 |
| Burst duration (s) | 3.8 ± 0.5 | 1.9 ± 0.7 | 6.2 ± 1.9 | P = 0.070 |
| Number of APs/burst | 22 ± 2.5 | 25 ± 7.7 | 54 ± 19.9 | P = 0.266 |
| Firing frequency in burst (Hz) | 13 ± 1.9 | 30 ± 7.1c | 16 ± 3.9 | P = 0.027 |
| Measurement . | Control (n = 25) . | Nonselective block of voltage-gated potassium channels (100 µM 4-AP; n = 8) . | D-type potassium channels blocked (100 nM ⍺-DTX; n = 9) . | Statistics . |
|---|---|---|---|---|
| ACSF-VM (mV) | −75 ± 1.2 | −76 ± 1.5 | −71 ± 1.1 | P = 0.152a |
| CCh-VM (mV) | −64 ± 1.0 | −66 ± 1.5 | −65 ± 0.7 | P = 0.613 |
| ΔACSF-CCh VM (mV) | 11 ± 1.0 | 10 ± 1.5 | 7 ± 0.9 | P = 0.058 |
| Depolarization rate (mV/min) | 6.5 ± 0.8 | 5.4 ± 0.8 | 3.4 ± 0.6 | P = 0.091 |
| Burst onset (min) | 6.4 ± 0.7 | 4.4 ± 1.0 | 6.1 ± 0.9 | P = 0.078a |
| Interburst interval (s) | 100 ± 14.7 | 119 ± 26.2 | 136 ± 33.0 | P = 0.512a |
| Burst-VM (mV) | −42 ± 1.0 | −37 ± 3.2 | −44 ± 0.9 | P = 0.067 |
| Interburst-VM (mV) | −62 ± 0.8 | −66 ± 1.5 | −64 ± 1.2 | P = 0.079a |
| Δburst-IBI VM (mV) | 22 ± 1.3 | 29 ± 3.2b | 20 ± 1.8 | P = 0.034a |
| Burst rise rate (mV/s) | 3.5 ± 0.5 | 97.5 ± 38.0c | 65.6 ± 33.4c | P < 0.001 |
| Burst decay rate (mV/s) | −4.6 ± 0.8 | −21.6 ± 5.0c | −13.3 ± 6.5 | P = 0.008 |
| Burst duration (s) | 3.8 ± 0.5 | 1.9 ± 0.7 | 6.2 ± 1.9 | P = 0.070 |
| Number of APs/burst | 22 ± 2.5 | 25 ± 7.7 | 54 ± 19.9 | P = 0.266 |
| Firing frequency in burst (Hz) | 13 ± 1.9 | 30 ± 7.1c | 16 ± 3.9 | P = 0.027 |