| Measurement . | Control (n = 25)a . | Excitatory transmission blocked (n = 7)b . | Inhibitory transmission blocked (n = 6)c . | Excitatory and inhibitory transmission blocked (n = 6)d . | Statistics . |
|---|---|---|---|---|---|
| ACSF-VM before CCh application (mV) | −75 ± 1.2 | −72 ± 3.1 | −80 ± 1.9 | −70 ± 4.1 | P = 0.054e |
| CCh-VM (mV) | −64 ± 1.0 | −62 ± 2.1 | −64 ± 1.5 | −57 ± 2.9f | P = 0.036e |
| ΔACSF-CCh VM (mV) | 11 ± 1.0 | 9.5 ± 1.5 | 16 ± 1.9 | 13 ± 1.4 | P = 0.065e |
| Depolarization rate (mV/min) | 6.5 ± 0.8 | 9.2 ± 3.4 | 9.4 ± 2.3 | 8.6 ± 2.0 | P = 0.52g |
| Burst onset (min) | 6.4 ± 0.7 | 4.6 ± 1.8 | 4.7 ± 1.2 | 3.5 ± 0.6 | P = 0.21e |
| Interburst interval (s) | 100 ± 14.7 | 36 ± 8.3h | 113 ± 41.9 | 36 ± 5.6h | P = 0.006g |
| Burst-VM (mV) | −42 ± 1.0 | −36 ± 1.6 | −42 ± 2.2 | −40 ± 3.2 | P = 0.41e |
| Interburst-VM (mV) | −62 ± 0.8 | −56 ± 1.4i | −63 ± 1.9 | −56 ± 1.1j | P < 0.001e |
| Δburst-IBI VM (mV) | 21 ± 1.2 | 18 ± 2.6 | 22 ± 3.7 | 14 ± 2.3 | P = 0.11e |
| Burst rise rate (mV/s) | 3.5 ± 0.5 | 5.9 ± 1.1 | 59 ± 26h | 3.6 ± 0.6 | P < 0.001g |
| Burst decay rate (mV/s) | −4.6 ± 0.8 | −4.3 ± 0.7 | −13.7 ± 4.0 | −4.8 ± 0.6 | P = 0.087g |
| Burst duration (s) | 3.8 ± 0.5 | 2.6 ± 0.7 | 1.1 ± 0.3h | 2.4 ± 0.6 | P = 0.037g |
| Number of APs/burst | 22 ± 2.5 | 11 ± 1.8h | 13 ± 2.3 | 11 ± 2.5h | P = 0.008g |
| Firing frequency in burst (Hz) | 13 ± 1.9 | 9.5 ± 1.4 | 36 ± 7.9h | 9.7 ± 4.5 | P = 0.012g |
| Measurement . | Control (n = 25)a . | Excitatory transmission blocked (n = 7)b . | Inhibitory transmission blocked (n = 6)c . | Excitatory and inhibitory transmission blocked (n = 6)d . | Statistics . |
|---|---|---|---|---|---|
| ACSF-VM before CCh application (mV) | −75 ± 1.2 | −72 ± 3.1 | −80 ± 1.9 | −70 ± 4.1 | P = 0.054e |
| CCh-VM (mV) | −64 ± 1.0 | −62 ± 2.1 | −64 ± 1.5 | −57 ± 2.9f | P = 0.036e |
| ΔACSF-CCh VM (mV) | 11 ± 1.0 | 9.5 ± 1.5 | 16 ± 1.9 | 13 ± 1.4 | P = 0.065e |
| Depolarization rate (mV/min) | 6.5 ± 0.8 | 9.2 ± 3.4 | 9.4 ± 2.3 | 8.6 ± 2.0 | P = 0.52g |
| Burst onset (min) | 6.4 ± 0.7 | 4.6 ± 1.8 | 4.7 ± 1.2 | 3.5 ± 0.6 | P = 0.21e |
| Interburst interval (s) | 100 ± 14.7 | 36 ± 8.3h | 113 ± 41.9 | 36 ± 5.6h | P = 0.006g |
| Burst-VM (mV) | −42 ± 1.0 | −36 ± 1.6 | −42 ± 2.2 | −40 ± 3.2 | P = 0.41e |
| Interburst-VM (mV) | −62 ± 0.8 | −56 ± 1.4i | −63 ± 1.9 | −56 ± 1.1j | P < 0.001e |
| Δburst-IBI VM (mV) | 21 ± 1.2 | 18 ± 2.6 | 22 ± 3.7 | 14 ± 2.3 | P = 0.11e |
| Burst rise rate (mV/s) | 3.5 ± 0.5 | 5.9 ± 1.1 | 59 ± 26h | 3.6 ± 0.6 | P < 0.001g |
| Burst decay rate (mV/s) | −4.6 ± 0.8 | −4.3 ± 0.7 | −13.7 ± 4.0 | −4.8 ± 0.6 | P = 0.087g |
| Burst duration (s) | 3.8 ± 0.5 | 2.6 ± 0.7 | 1.1 ± 0.3h | 2.4 ± 0.6 | P = 0.037g |
| Number of APs/burst | 22 ± 2.5 | 11 ± 1.8h | 13 ± 2.3 | 11 ± 2.5h | P = 0.008g |
| Firing frequency in burst (Hz) | 13 ± 1.9 | 9.5 ± 1.4 | 36 ± 7.9h | 9.7 ± 4.5 | P = 0.012g |
10 µM CCh.
10 µM CCh, 10 µM NBQX, and 50 µM APV.
10 µM CCh, 1 µM SR95531, and 2 µM CGP5584A.
10 µM CCh, 10 µM NBQX, 50 µM APV, 1 µM SR95531, and 2 µM CGP5584A.
One-way ANOVA.
P = 0.025 vs. CT; Tukey post hoc test.
Kruskal–Wallis test.
P < 0.05 vs. CT; Dunn–Holland–Wolfe post hoc test.
P = 0.001 vs. CT; P = 0.013 vs. SR; Tukey post hoc test.
P = 0.006 vs. CT; P = 0.033 vs. SR; Tukey post hoc test.