Table 2. Summary of effects of PUFA... | Rockefeller University Press

Table 2.

Summary of effects of PUFA analogues on the cardiac I_Ks channel

PUFA name	I/I₀	ΔV_0.5 (mV)	G_max/G_max₀	n
Linoleic acid	0.5 ± 0.04	4.7 ± 0.9	0.7 ± 0.04	5
Lin-glycine	5.3 ± 0.5	−26.4 ± 4.4	2.4 ± 0.2	4
Lin-taurine	10.4 ± 4.0	−73.1 ± 2.6	2.0 ± 0.6	3
Lin-glycine+1C	1.7 ± 0.2	−7.2 ± 2.5	1.3 ± 0.02	3
Lin-glycine+2C	1.9 ± 0.4	−8.7 ± 0.5	1.1 ± 0.2	3
Lin-cysteic acid	9.2 ± 0.4	−58.4 ± 2.8	2.0 ± 0.2	5
Lin-aspartate	4.0 ± 0.1	−34.5 ± 2.3	1.4 ± 0.1	4
Lin-AP3	1.8 ± 0.3	−5.7 ± 1.3	1.1 ± 0.1	3
DHA	2.0 ± 0.6	0.1 ± 1.4	1.7 ± 0.3	4
DHA-glycine	4.7 ± 1.3	−16.5 ± 1.3	2.0 ± 0.2	4
DHA-taurine	5.1 ± 0.7	−45.3 ± 2.9	1.7 ± 0.1	3
Pinolenic acid	1.5 ± 0.3	−6 ± 1.8	1.4 ± 0.2	3
Pin-glycine	3.8 ± 0.2	−21.1 ± 2.5	1.8 ± 0.1	3
Pin-taurine	9.0 ± 1.4	51.6 ± 3.5	1.9 ± 0.3	4

PUFA name	I/I₀	ΔV_0.5 (mV)	G_max/G_max₀	n
Linoleic acid	0.5 ± 0.04	4.7 ± 0.9	0.7 ± 0.04	5
Lin-glycine	5.3 ± 0.5	−26.4 ± 4.4	2.4 ± 0.2	4
Lin-taurine	10.4 ± 4.0	−73.1 ± 2.6	2.0 ± 0.6	3
Lin-glycine+1C	1.7 ± 0.2	−7.2 ± 2.5	1.3 ± 0.02	3
Lin-glycine+2C	1.9 ± 0.4	−8.7 ± 0.5	1.1 ± 0.2	3
Lin-cysteic acid	9.2 ± 0.4	−58.4 ± 2.8	2.0 ± 0.2	5
Lin-aspartate	4.0 ± 0.1	−34.5 ± 2.3	1.4 ± 0.1	4
Lin-AP3	1.8 ± 0.3	−5.7 ± 1.3	1.1 ± 0.1	3
DHA	2.0 ± 0.6	0.1 ± 1.4	1.7 ± 0.3	4
DHA-glycine	4.7 ± 1.3	−16.5 ± 1.3	2.0 ± 0.2	4
DHA-taurine	5.1 ± 0.7	−45.3 ± 2.9	1.7 ± 0.1	3
Pinolenic acid	1.5 ± 0.3	−6 ± 1.8	1.4 ± 0.2	3
Pin-glycine	3.8 ± 0.2	−21.1 ± 2.5	1.8 ± 0.1	3
Pin-taurine	9.0 ± 1.4	51.6 ± 3.5	1.9 ± 0.3	4

Summary of the effects of PUFAs on I_Ks I/I₀, ΔV_0.5 (mV), and G_max/G_max0 with the number of experiments (n). Data are represented as mean ± SEM at the maximum concentration used (effects of DHA-taurine are reported at 7 µM due to a decrease in current observed at 20 µM).

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