| PUFA . | pKa1 . | pKa2 . | pKa3 . |
|---|---|---|---|
| Linoleic acid | 8.5 | NA | NA |
| Lin-glycine | 7.6 | NA | NA |
| Lin-taurine | 2.7 | NA | NA |
| Lin-glycine+1C | 8.0 | NA | NA |
| Lin-glycine+2C | 8.0 | NA | NA |
| Lin-aspartate | 7.6 | 9.1 | NA |
| Lin-cysteic acid | 2.6 | 7.1 | NA |
| Lin-AP3 | 5.0 | 7.7 | 11.8 |
| DHA | 8.3 | NA | NA |
| DHA-glycine | 7.5 | NA | NA |
| DHA-taurine | 2.8 | NA | NA |
| Pinolenic acid | 8.4 | NA | NA |
| Pin-glycine | 7.5 | NA | NA |
| Pin-taurine | 2.8 | NA | NA |
| PUFA . | pKa1 . | pKa2 . | pKa3 . |
|---|---|---|---|
| Linoleic acid | 8.5 | NA | NA |
| Lin-glycine | 7.6 | NA | NA |
| Lin-taurine | 2.7 | NA | NA |
| Lin-glycine+1C | 8.0 | NA | NA |
| Lin-glycine+2C | 8.0 | NA | NA |
| Lin-aspartate | 7.6 | 9.1 | NA |
| Lin-cysteic acid | 2.6 | 7.1 | NA |
| Lin-AP3 | 5.0 | 7.7 | 11.8 |
| DHA | 8.3 | NA | NA |
| DHA-glycine | 7.5 | NA | NA |
| DHA-taurine | 2.8 | NA | NA |
| Pinolenic acid | 8.4 | NA | NA |
| Pin-glycine | 7.5 | NA | NA |
| Pin-taurine | 2.8 | NA | NA |
Estimated pKa values for PUFAs and PUFA analogues associated with the cardiac IKs channel were calculated by adding a factor of 3.5 to the starting pKa value calculated in solution.