Table 1.
Parameter estimates resulting from fitting Eq. 7 to step force responses recorded in skinned mouse myocardium exposed to varying Pi at approximately half Ca2+ activation, pCa 5.9
ConditionGp (mN · mm−2)kpLhsγg1A¯0f0 (mN · mm−2)LhsλA¯0 (mN · mm−2)f0 + g0 (s−1)g0 (s−1)f0 (s−1)
[Pi] (mM)        
1.0 142 0.154 37.2 3.25 80.6 67.2 13.4 
2.0 139 0.159 35.4 2.91 84.3 70.1 14.2 
3.0 141 0.154 34.2 2.78 86.4 71.9 14.5 
4.0 143 0.149 36.6 2.53 89.3 75.9 13.4 
5.0 139 0.157 38.2 2.21 90.3 77.7 12.6 
8.0 144 0.148 49.2 2.43 93.6 83.1 10.5 
r 0.527 −0.587 0.842 0.808 0.962 0.990 0.862 
0.283 0.288 0.036 0.049 0.002 <0.001 0.027 
ConditionGp (mN · mm−2)kpLhsγg1A¯0f0 (mN · mm−2)LhsλA¯0 (mN · mm−2)f0 + g0 (s−1)g0 (s−1)f0 (s−1)
[Pi] (mM)        
1.0 142 0.154 37.2 3.25 80.6 67.2 13.4 
2.0 139 0.159 35.4 2.91 84.3 70.1 14.2 
3.0 141 0.154 34.2 2.78 86.4 71.9 14.5 
4.0 143 0.149 36.6 2.53 89.3 75.9 13.4 
5.0 139 0.157 38.2 2.21 90.3 77.7 12.6 
8.0 144 0.148 49.2 2.43 93.6 83.1 10.5 
r 0.527 −0.587 0.842 0.808 0.962 0.990 0.862 
0.283 0.288 0.036 0.049 0.002 <0.001 0.027 

The correlation coefficient, r, refers to the Pearson coefficient between the given parameter and Pi condition; r values shown in bold demonstrate statistical significance at P < 0.05.

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