Table 1. Half-maximal concentrations for... | Rockefeller University Press

Table 1.

Half-maximal concentrations for Cd activation and inhibition

Construct	EC₅₀ (µM)	Slope, n	IC₅₀ (mM)	Slope, b	Cells (no.)
K2(Q) WT (KA-evoked)			0.89 ± 0.08	1.1 ± 0.1	5
K2(R) WT (KA-evoked)			0.25 ± 0.04	1.0 ± 0.1	4
K2(Q&R) A8C	7.3 ± 1.4	1.6 ± 0.4	25 ± 5.4	1.3 ± 0.4	23
K2(Q) L10C	1,800 ± 300	1.2 ± 0.2	26 ± 7.1	1.9 ± 0.5	12
N1/K2 A8C + N2B/K2 A8C	5.6 ± 1.7	0.9 ± 0.1	1.1 ± 0.2	1.8 ± 0.4	21
N1/K2 A8C + N2B/K2	47 ± 8	1.0 ± 0.2	13 ± 10	0.9 ± 0.4	14
N1/K2 + N2B/K2 A8C	27 ± 9	0.9 ± 0.1	1.1 ± 0.2	1.8 ± 0.4	14

Construct	EC₅₀ (µM)	Slope, n	IC₅₀ (mM)	Slope, b	Cells (no.)
K2(Q) WT (KA-evoked)			0.89 ± 0.08	1.1 ± 0.1	5
K2(R) WT (KA-evoked)			0.25 ± 0.04	1.0 ± 0.1	4
K2(Q&R) A8C	7.3 ± 1.4	1.6 ± 0.4	25 ± 5.4	1.3 ± 0.4	23
K2(Q) L10C	1,800 ± 300	1.2 ± 0.2	26 ± 7.1	1.9 ± 0.5	12
N1/K2 A8C + N2B/K2 A8C	5.6 ± 1.7	0.9 ± 0.1	1.1 ± 0.2	1.8 ± 0.4	21
N1/K2 A8C + N2B/K2	47 ± 8	1.0 ± 0.2	13 ± 10	0.9 ± 0.4	14
N1/K2 + N2B/K2 A8C	27 ± 9	0.9 ± 0.1	1.1 ± 0.2	1.8 ± 0.4	14