Table 6.
Single channel parameters for different agonists
AgonistUnitary current (pA)SDopenRelative SDn
ATP −3.51 ± 0.2 1.02 ± 0.1 0.32 ± 0.03 20 
CTP −3.98 ± 0.3 0.99 ± 0.1 0.25 ± 0.01 
GTP −3.82 ± 0.4 0.90 ± 0.1 0.23 ± 0.02 
UTP −3.04 ± 0.3 0.93 ± 0.1 0.31 ± 0.02 
LNA-ATP −3.58 ± 0.4 1.03 ± 0.1 0.32 ± 0.04 
C2′-F-dATP −4.00 ± 0.3 1.23 ± 0.1 0.31 ± 0.03 
Ara-ATP −3.94 ± 0.3 1.05 ± 0.1 0.27 ± 0.03 
AgonistUnitary current (pA)SDopenRelative SDn
ATP −3.51 ± 0.2 1.02 ± 0.1 0.32 ± 0.03 20 
CTP −3.98 ± 0.3 0.99 ± 0.1 0.25 ± 0.01 
GTP −3.82 ± 0.4 0.90 ± 0.1 0.23 ± 0.02 
UTP −3.04 ± 0.3 0.93 ± 0.1 0.31 ± 0.02 
LNA-ATP −3.58 ± 0.4 1.03 ± 0.1 0.32 ± 0.04 
C2′-F-dATP −4.00 ± 0.3 1.23 ± 0.1 0.31 ± 0.03 
Ara-ATP −3.94 ± 0.3 1.05 ± 0.1 0.27 ± 0.03 

Unitary channel current, SDopen, and relative SD (calculated as SDopen/unitary current) are shown (mean ± SEM) for selected agonists, along with the number of experiments (n). Concentrations used: ATP (1 µM), CTP (10 µM), GTP (100 µM), UTP (10 µM), LNA-ATP (1 µM), C2′-F-dATP (10 µM), and Ara-ATP (1 µM).

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