Table 5.
Energy efficiencies (η, for the native agonist) and intrinsic gating energies (ΔG0)
Receptorη %ΔG0 (kcal/mol)
Endplate AChR   
Human   
 α−ε 47 8.4 
 α−δ 51 
 α−γ 56 9.6 (w/α−δ) 
Mouse   
 α−ε 55 8.4 
 α−δ 58 
 α−γ 59 9.8 (w/α−δ) 
Human α1β2γ2S GABAA receptor 39 1.9 
Human NR1A/NR2A NMDA receptor (unliganded Glu site, Gly site saturated) 49 3.6 
Human NR1A/NR2A NMDA receptor (unliganded Gly site, Glu site saturated) 57 9.3 
Human M3 muscarinic receptor 52 5.4 
Human α1 GlyR 59 4.5 
Fish aryl-hydrocarbon nuclear receptor 50 12.3 
Receptorη %ΔG0 (kcal/mol)
Endplate AChR   
Human   
 α−ε 47 8.4 
 α−δ 51 
 α−γ 56 9.6 (w/α−δ) 
Mouse   
 α−ε 55 8.4 
 α−δ 58 
 α−γ 59 9.8 (w/α−δ) 
Human α1β2γ2S GABAA receptor 39 1.9 
Human NR1A/NR2A NMDA receptor (unliganded Glu site, Gly site saturated) 49 3.6 
Human NR1A/NR2A NMDA receptor (unliganded Gly site, Glu site saturated) 57 9.3 
Human M3 muscarinic receptor 52 5.4 
Human α1 GlyR 59 4.5 
Fish aryl-hydrocarbon nuclear receptor 50 12.3 

ΔG0 values for endplate AChRs are for adult (α−ε and α−δ) or fetal types (α−γ).

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