Table 1. Ca 2 -dependent activation of... | Rockefeller University Press

Table 1.

Ca²⁺-dependent activation of WT TMEM16F and aromatic Q559 mutants using the three-pulse protocol

Channel	Ca²⁺ dose–response
	K_1/2 (µM)	Hill coefficient
WT_16Fa	34 ± 3	1.2 ± 0.1
Q559F_16F	10 ± 1	1.5 ± 0.1
Q559Y_16F	7.9 ± 0.9	1.3 ± 0.1
Q559H_16F	3.2 ± 0.6	1.9 ± 0.2
Q559W_16F	2.2 ± 0.7	0.9 ± 0.2

Channel	Ca²⁺ dose–response
	K_1/2 (µM)	Hill coefficient
WT_16Fa	34 ± 3	1.2 ± 0.1
Q559F_16F	10 ± 1	1.5 ± 0.1
Q559Y_16F	7.9 ± 0.9	1.3 ± 0.1
Q559H_16F	3.2 ± 0.6	1.9 ± 0.2
Q559W_16F	2.2 ± 0.7	0.9 ± 0.2

aChannel likely in partially rundown state.