Table 1. Summary of mechanical... | Rockefeller University Press

Table 1.

Summary of mechanical properties of right ventricular trabeculae isolated from the hearts of ENH^+/+ and ENH^−/− mice

Number of trabeculae	Passive tension (mN/mm²)	Maximum Ca²⁺ activated tension (mN/mm²)	Hill coefficient (n_H)	Ca²⁺ sensitivity of tension (pCa₅₀)	Maximum rate of tension redevelopment (s⁻¹)
ENH^+/+, n = 15	1.83 ± 0.17	22.34 ± 1.85	2.69 ± 0.06	5.73 ± 0.01	32.33 ± 1.94
ENH^−/−, n = 20	2.06 ± 0.18	17.85 ± 1.48	2.69 ± 0.04	5.75 ± 0.01	19.80 ± 1.17^{^a}

Number of trabeculae	Passive tension (mN/mm²)	Maximum Ca²⁺ activated tension (mN/mm²)	Hill coefficient (n_H)	Ca²⁺ sensitivity of tension (pCa₅₀)	Maximum rate of tension redevelopment (s⁻¹)
ENH^+/+, n = 15	1.83 ± 0.17	22.34 ± 1.85	2.69 ± 0.06	5.73 ± 0.01	32.33 ± 1.94
ENH^−/−, n = 20	2.06 ± 0.18	17.85 ± 1.48	2.69 ± 0.04	5.75 ± 0.01	19.80 ± 1.17^{^a}

The mechanical properties of skinned trabeculae isolated from the right ventricles of ENH^+/+ (n = 11) and ENH^−/− (n = 12) mice were examined at SL 2.2 µm and 22°C. Passive tension was measured at pCa 9.0. P_o and k_tr were measured at pCa 4.5. pCa₅₀ and n_H values were derived by fitting the tension–pCa relationships to a Hill equation as described in Materials and methods.

The measured values were significantly different (P < 0.05) from values recorded in ENH^+/+ trabeculae.

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