| . | qij . | |||||||
|---|---|---|---|---|---|---|---|---|
| q0 . | q1 . | q2 . | q3 . | q10 . | q11 . | q12 . | q13 . | |
| State | E | EH | EHH | EHHH | ES | ESH | ESHH | ESHHH |
| (SH3) | α3γ3 | 3α3γ3 | 3α2γ3 | γ3 | α3γ3 | 3α3γ2 | 3α2γ | 1 |
| (SH3)a | 1 | 3 | 3 | 1 | 1 | 3 | 3 | 1 |
| (SH2)H | αβγ2 | 2αβγ2 | βγ2 | 0 | αβγ2 | 2αβγ | β | 1 |
| (SH)(H2) | αβ2γ | αβ2γ | 0 | 0 | αβ2γ | αβ2 | 2αβ | 1 |
| (SH)HH | β1β/γ | β1β2γ | 0 | 0 | β1β2γ | β1β2 | β2 | 1 |
| H(SH2) | αβ2γ2 | αβ2γ2 | 2αβγ2 | γ2 | 0 | αβ2γ2 | 2αβγ | 1 |
| (H2)(SH) | αβγ | 2αβγ | βγ | γ | 0 | 0 | βγ | 1 |
| HH(SH) | β1β2γ | β1β2γ | β2γ | γ | 0 | 0 | β2γ | 1 |
| H(SH)H | β1β2γ | β1β2γ | β2γ | 0 | 0 | β1β2γ | β2 | 1 |
| (H3)S | α3 | 3α3 | 3α2 | 1 | 0 | 0 | 0 | 1 |
| (H2)HS | αβ | 2αβ | β | 1 | 0 | 0 | 0 | 1 |
| H(H2)S | αβ2 | αβ2 | 2αβ | 1 | 0 | 0 | 0 | 1 |
| HHHS | β1β2 | β1β2 | β2 | 1 | 0 | 0 | 0 | 1 |
| (H2)SH | αβ | 2αβ | β | 0 | 0 | 0 | β | 1 |
| HHSH | β1β2 | β1β2 | β2 | 0 | 0 | 0 | β2 | 1 |
| HS(H2) | αβ2 | αβ2 | 0 | 0 | 0 | αβ2 | 2αβ | 1 |
| HSHH | β1β2 | β1β2 | 0 | 0 | 0 | β1β2 | β2 | 1 |
| S(H3) | α3 | 0 | 0 | 0 | α3 | 3 α3 | 3 α2 | 1 |
| S(H2)H | αβ | 0 | 0 | 0 | αβ | 2αβ | β | 1 |
| SH(H2) | αβ2 | 0 | 0 | 0 | αβ2 | αβ2 | 2αβ | 1 |
| SHHH | β1β2 | 0 | 0 | 0 | β1β2 | β1β2 | β2 | 1 |
| . | qij . | |||||||
|---|---|---|---|---|---|---|---|---|
| q0 . | q1 . | q2 . | q3 . | q10 . | q11 . | q12 . | q13 . | |
| State | E | EH | EHH | EHHH | ES | ESH | ESHH | ESHHH |
| (SH3) | α3γ3 | 3α3γ3 | 3α2γ3 | γ3 | α3γ3 | 3α3γ2 | 3α2γ | 1 |
| (SH3)a | 1 | 3 | 3 | 1 | 1 | 3 | 3 | 1 |
| (SH2)H | αβγ2 | 2αβγ2 | βγ2 | 0 | αβγ2 | 2αβγ | β | 1 |
| (SH)(H2) | αβ2γ | αβ2γ | 0 | 0 | αβ2γ | αβ2 | 2αβ | 1 |
| (SH)HH | β1β/γ | β1β2γ | 0 | 0 | β1β2γ | β1β2 | β2 | 1 |
| H(SH2) | αβ2γ2 | αβ2γ2 | 2αβγ2 | γ2 | 0 | αβ2γ2 | 2αβγ | 1 |
| (H2)(SH) | αβγ | 2αβγ | βγ | γ | 0 | 0 | βγ | 1 |
| HH(SH) | β1β2γ | β1β2γ | β2γ | γ | 0 | 0 | β2γ | 1 |
| H(SH)H | β1β2γ | β1β2γ | β2γ | 0 | 0 | β1β2γ | β2 | 1 |
| (H3)S | α3 | 3α3 | 3α2 | 1 | 0 | 0 | 0 | 1 |
| (H2)HS | αβ | 2αβ | β | 1 | 0 | 0 | 0 | 1 |
| H(H2)S | αβ2 | αβ2 | 2αβ | 1 | 0 | 0 | 0 | 1 |
| HHHS | β1β2 | β1β2 | β2 | 1 | 0 | 0 | 0 | 1 |
| (H2)SH | αβ | 2αβ | β | 0 | 0 | 0 | β | 1 |
| HHSH | β1β2 | β1β2 | β2 | 0 | 0 | 0 | β2 | 1 |
| HS(H2) | αβ2 | αβ2 | 0 | 0 | 0 | αβ2 | 2αβ | 1 |
| HSHH | β1β2 | β1β2 | 0 | 0 | 0 | β1β2 | β2 | 1 |
| S(H3) | α3 | 0 | 0 | 0 | α3 | 3 α3 | 3 α2 | 1 |
| S(H2)H | αβ | 0 | 0 | 0 | αβ | 2αβ | β | 1 |
| SH(H2) | αβ2 | 0 | 0 | 0 | αβ2 | αβ2 | 2αβ | 1 |
| SHHH | β1β2 | 0 | 0 | 0 | β1β2 | β1β2 | β2 | 1 |
The top part shows mechanisms with random binding of the substrate and (part of) the co-ions, and the bottom part shows mechanisms with ordered binding of the substrate. Bold entries show the q parameters for co-ion binding in the response model (Online supplementary material file S3).
Fully random with no interaction between the sites: α = 1, γ = 1.