| Construct . | V1/2 . | k . | Time to half max (s) . | Time to half max (SEM) . | Time constant of deactivation 1 (ms) . | Time constant of deactivation 1 (SEM) . | Time constant of deactivation 2 (ms) . | Time constant of deactivation 2 (SEM) . |
|---|---|---|---|---|---|---|---|---|
| hERGΔPAS | 16.1± 1.6 (3) | 19.1 ± 1.5 (3) | 0.35 (3) | 0.0043 | 21.68 (4) | 7.21 | 47.21 (3) | 13.27 |
| PAS + hERGΔPAS | 10.9 ± 1.3 (3) | 17.3 ± 1.2 (3) | 0.32 (3) | 0. 0091 | 72.43 (5) | 6.73 | 201.47 (3) | 10.00 |
| WT | 16.0 ± 0.9 (3) | 16.2 ± 0.8 (3) | 0.38 (4) | 0.0236 | 96.00 (3) | 8.19 | 205.01 (4) | 23.16 |
| hERG ΔPAS F860A | 9.4 ± 3.00 (3) | 22.6 ± 3.2 (3) | 0.31 (3) | 0.0069 | 15.97 (4) | 2.42 | 119.61 (3) | 24.23 |
| PAS + hERGΔPAS F860A | 8.5 ± 2.2 (3) | 22.3 ± 2.3 (3) | 0.33 (3) | 0.0100 | 37.72 (3) | 8.69 | 76.04 (3) | 16.47 |
| hERG ΔPAS L862A | −3.0 ± 3.7 (4) | 18.7 ± 1.7 (4) | 0.27 (3) | 0.0037 | 4.59 (3) | 1.97 | 38.96 (3) | 14.49 |
| PAS + hERG ΔPAS L862A | −5.0 ± 1.7 (3) | 15.7 ± 2.0 (3) | 0.25 (3) | 0.0028 | 1.45 (3) | 0.15 | 15.65 (3) | 3.58 |
| hERG ΔPAS F860G L862G | −6.6 ± 2.3 (3) | 22.10 ± 2.4 (3) | 0.25 (3) | 0.0032 | 4.99 (3) | 2.09 | 40.77 (3) | 14.71 |
| PAS + hERG ΔPAS F860G L862G | −3.0 ± 3.7 (3) | 26.5 ± 4.3 (3) | 0.25 (3) | 0.0010 | 7.39 (3) | 3.53 | 91.89 (3) | 40.48 |
| Construct . | V1/2 . | k . | Time to half max (s) . | Time to half max (SEM) . | Time constant of deactivation 1 (ms) . | Time constant of deactivation 1 (SEM) . | Time constant of deactivation 2 (ms) . | Time constant of deactivation 2 (SEM) . |
|---|---|---|---|---|---|---|---|---|
| hERGΔPAS | 16.1± 1.6 (3) | 19.1 ± 1.5 (3) | 0.35 (3) | 0.0043 | 21.68 (4) | 7.21 | 47.21 (3) | 13.27 |
| PAS + hERGΔPAS | 10.9 ± 1.3 (3) | 17.3 ± 1.2 (3) | 0.32 (3) | 0. 0091 | 72.43 (5) | 6.73 | 201.47 (3) | 10.00 |
| WT | 16.0 ± 0.9 (3) | 16.2 ± 0.8 (3) | 0.38 (4) | 0.0236 | 96.00 (3) | 8.19 | 205.01 (4) | 23.16 |
| hERG ΔPAS F860A | 9.4 ± 3.00 (3) | 22.6 ± 3.2 (3) | 0.31 (3) | 0.0069 | 15.97 (4) | 2.42 | 119.61 (3) | 24.23 |
| PAS + hERGΔPAS F860A | 8.5 ± 2.2 (3) | 22.3 ± 2.3 (3) | 0.33 (3) | 0.0100 | 37.72 (3) | 8.69 | 76.04 (3) | 16.47 |
| hERG ΔPAS L862A | −3.0 ± 3.7 (4) | 18.7 ± 1.7 (4) | 0.27 (3) | 0.0037 | 4.59 (3) | 1.97 | 38.96 (3) | 14.49 |
| PAS + hERG ΔPAS L862A | −5.0 ± 1.7 (3) | 15.7 ± 2.0 (3) | 0.25 (3) | 0.0028 | 1.45 (3) | 0.15 | 15.65 (3) | 3.58 |
| hERG ΔPAS F860G L862G | −6.6 ± 2.3 (3) | 22.10 ± 2.4 (3) | 0.25 (3) | 0.0032 | 4.99 (3) | 2.09 | 40.77 (3) | 14.71 |
| PAS + hERG ΔPAS F860G L862G | −3.0 ± 3.7 (3) | 26.5 ± 4.3 (3) | 0.25 (3) | 0.0010 | 7.39 (3) | 3.53 | 91.89 (3) | 40.48 |