Table 3. Estimate of the apparent rate... | Rockefeller University Press

Table 3.

Estimate of the apparent rate of cross bridge attachment (f_app) and duty ratio (proportional to maximal tension) from myofibril kinetic measurements

Myofibril type	g_app(α Tc)	f_app	Estimated duty ratio (α P₀)
	slowk_REL	(k_ACT-slow k_REL)	(f_app/f_app+g_app)
Donors (N = 5)	0.29 ± 0.02 (95)	0.55 ± 0.03 (93)	0.63 ± 0.02 (93)
LVH_ao (N = 7)	0.20 ± 0.02 (54)	0.39 ± 0.04 (34)	0.675 ± 0.05 (34)
HCM_smn (N = 3)	0.30 ± 0.02 (44)	0.43 ± 0.04 (42)	0.56 ± 0.04 (42)
K280N (N = 1)	0.63 ± 0.05* (42)	1.14 ± 0.08 (38)*	0.635 ± 0.03 (38)

Myofibril type	g_app(α Tc)	f_app	Estimated duty ratio (α P₀)
	slowk_REL	(k_ACT-slow k_REL)	(f_app/f_app+g_app)
Donors (N = 5)	0.29 ± 0.02 (95)	0.55 ± 0.03 (93)	0.63 ± 0.02 (93)
LVH_ao (N = 7)	0.20 ± 0.02 (54)	0.39 ± 0.04 (34)	0.675 ± 0.05 (34)
HCM_smn (N = 3)	0.30 ± 0.02 (44)	0.43 ± 0.04 (42)	0.56 ± 0.04 (42)
K280N (N = 1)	0.63 ± 0.05* (42)	1.14 ± 0.08 (38)*	0.635 ± 0.03 (38)

Means ± SE; N, number of patients in the group; numbers in parenthesis are the numbers of myofibrils in each group. *, f_app is significantly higher in K280N myofibrils versus all control groups.

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