Table 2. Mechanical and energetic... | Rockefeller University Press

Table 2.

Mechanical and energetic parameters of permeabilized ventricular strips from the homozygous K280N cTnT HCM patient and three groups of control patients

	K280N (N = 1, n = 16)	Donors (N = 2, n = 12)	LVH_ao (N = 3, n = 13)	HCM_smn (N = 6, n = 29)
Maximal tension (kN m⁻²)	13.5 ± 1.8*	38.7 ± 1.2	21.3 ± 1.5	25.6 ± 1.6
Maximal ATPase activity (μmol L⁻¹ s⁻¹)	38.4 ± 4.8	91.0 ± 4.7	52.2 ± 6.3	45.2 ± 2.7
Tension cost (μmol L⁻¹ s⁻¹/ kN m⁻²)	3.1 ± 0.3*	2.3 ± 0.1	2.5 ± 0.3	1.8 ± 0.1
Basal ATPase activity (μmol L⁻¹ s⁻¹)	4.6 ± 0.8	10.9 ± 2.1	10.3 ± 2.2	7.2 ± 1.0

	K280N (N = 1, n = 16)	Donors (N = 2, n = 12)	LVH_ao (N = 3, n = 13)	HCM_smn (N = 6, n = 29)
Maximal tension (kN m⁻²)	13.5 ± 1.8*	38.7 ± 1.2	21.3 ± 1.5	25.6 ± 1.6
Maximal ATPase activity (μmol L⁻¹ s⁻¹)	38.4 ± 4.8	91.0 ± 4.7	52.2 ± 6.3	45.2 ± 2.7
Tension cost (μmol L⁻¹ s⁻¹/ kN m⁻²)	3.1 ± 0.3*	2.3 ± 0.1	2.5 ± 0.3	1.8 ± 0.1
Basal ATPase activity (μmol L⁻¹ s⁻¹)	4.6 ± 0.8	10.9 ± 2.1	10.3 ± 2.2	7.2 ± 1.0

Means ± SE; N, number of patients in the group; n, number of muscle strips. For the statistics of the comparison between groups, see Supplemental materials; *, K280N parameters for which the statistical analysis shows a significant difference versus control groups.

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