| Myofibril type . | RT . | P0 . | kACT . | Dslow . | slow kREL . | fast kREL . |
|---|---|---|---|---|---|---|
| kN m−2 | kN m−2 | s−1 | ms | s−1 | s−1 | |
| Donors (N = 5) | 10.4 ± 0.6 (n = 98) | 111 ± 5 (n = 96) | 0.85 ± 0.02 (n = 118) | 186 ± 5 (n = 100) | 0.29 ± 0.02 (n = 95) | 4.18 ± 0.14 (n = 101) |
| LVHao (N = 7) | 9.8 ± 1.1 (n = 48) | 96 ± 6 (n = 58) | 0.71 ± 0.04 (n = 50) | 248 ± 13 (n = 54) | 0.20 ± 0.02 (n = 54) | 3.15 ± 0.20 (n = 54) |
| HCMsmn (N = 3) | 8.2 ± 0.9 (n = 44) | 87 ± 7 (n = 43) | 0.74 ± 0.03 (n = 45) | 206 ± 7 (n = 44) | 0.30 ± 0.02 (n = 44) | 4.62 ± 0.20 (n = 44) |
| K280N (N = 1) | 14.9 ± 1.4* (n = 43) | 87 ± 5 (n = 43) | 1.73 ± 0.07* (n = 39) | 226 ± 11 (n = 43) | 0.63 ± 0.05* (n = 42) | 3.76 ± 0.16 (n = 42) |
| Tn-exchanged batches | ||||||
| K280N sham treated (N = 1) | 15.9 ± 2.9 (n = 12) | 89 ± 9 (n = 12) | 1.69 ± 0.08 (n = 17) | 240 ± 16 (n = 16) | 0.69 ± 0.08 (n = 16) | 3.90 ± 0.27 (n = 16) |
| K280N WT Tn exch (N = 1) | 15.7 ± 2.0 (n = 13) | 86 ± 7 (n = 14) | 1.00 ± 0.09++ (n = 16) | 259 ± 27 (n = 15) | 0.31 ± 0.05++ (n = 16) | 3.13 ± 0.19+ (n = 16) |
| Donors sham treated (N = 2) | 10.5 ± 0.83 (n = 64) | 114 ± 7 (n = 62) | 0.86 ± 0.03 (n = 70) | 173 ± 6 (n = 62) | 0.28 ± 0.02 (n = 58) | 4.26 ± 0.18 (n = 63) |
| Donors WT Tn exch (N = 2) | 10.1 ± 0.7 (n = 72) | 91 ± 6+ (n = 63) | 0.84 ± 0.03 (n = 70) | 179 ± 8 (n = 59) | 0.30 ± 0.02 (n = 66) | 4.65 ± 0.19 (n = 65) |
| Donor sham treated (N = 1) | 10.8 ± 1.1 (n = 14) | 94 ± 10 (n = 14) | 0.81 ± 0.04 (n = 15) | 214 ± 7 (n = 15) | 0.33 ± 0.04 (n = 15) | 3.78 ± 0.32 (n = 15) |
| Donor K280N Tn exch (N = 1) | 15.9 ± 1.9+ (n = 12) | 77 ± 9 (n = 10) | 1.04±0.08++ (n = 12) | 186 ± 9+ (n = 12) | 0.60 ± 0.07++ (n = 13) | 4.18 ± 0.62 (n = 13) |
| Myofibril type . | RT . | P0 . | kACT . | Dslow . | slow kREL . | fast kREL . |
|---|---|---|---|---|---|---|
| kN m−2 | kN m−2 | s−1 | ms | s−1 | s−1 | |
| Donors (N = 5) | 10.4 ± 0.6 (n = 98) | 111 ± 5 (n = 96) | 0.85 ± 0.02 (n = 118) | 186 ± 5 (n = 100) | 0.29 ± 0.02 (n = 95) | 4.18 ± 0.14 (n = 101) |
| LVHao (N = 7) | 9.8 ± 1.1 (n = 48) | 96 ± 6 (n = 58) | 0.71 ± 0.04 (n = 50) | 248 ± 13 (n = 54) | 0.20 ± 0.02 (n = 54) | 3.15 ± 0.20 (n = 54) |
| HCMsmn (N = 3) | 8.2 ± 0.9 (n = 44) | 87 ± 7 (n = 43) | 0.74 ± 0.03 (n = 45) | 206 ± 7 (n = 44) | 0.30 ± 0.02 (n = 44) | 4.62 ± 0.20 (n = 44) |
| K280N (N = 1) | 14.9 ± 1.4* (n = 43) | 87 ± 5 (n = 43) | 1.73 ± 0.07* (n = 39) | 226 ± 11 (n = 43) | 0.63 ± 0.05* (n = 42) | 3.76 ± 0.16 (n = 42) |
| Tn-exchanged batches | ||||||
| K280N sham treated (N = 1) | 15.9 ± 2.9 (n = 12) | 89 ± 9 (n = 12) | 1.69 ± 0.08 (n = 17) | 240 ± 16 (n = 16) | 0.69 ± 0.08 (n = 16) | 3.90 ± 0.27 (n = 16) |
| K280N WT Tn exch (N = 1) | 15.7 ± 2.0 (n = 13) | 86 ± 7 (n = 14) | 1.00 ± 0.09++ (n = 16) | 259 ± 27 (n = 15) | 0.31 ± 0.05++ (n = 16) | 3.13 ± 0.19+ (n = 16) |
| Donors sham treated (N = 2) | 10.5 ± 0.83 (n = 64) | 114 ± 7 (n = 62) | 0.86 ± 0.03 (n = 70) | 173 ± 6 (n = 62) | 0.28 ± 0.02 (n = 58) | 4.26 ± 0.18 (n = 63) |
| Donors WT Tn exch (N = 2) | 10.1 ± 0.7 (n = 72) | 91 ± 6+ (n = 63) | 0.84 ± 0.03 (n = 70) | 179 ± 8 (n = 59) | 0.30 ± 0.02 (n = 66) | 4.65 ± 0.19 (n = 65) |
| Donor sham treated (N = 1) | 10.8 ± 1.1 (n = 14) | 94 ± 10 (n = 14) | 0.81 ± 0.04 (n = 15) | 214 ± 7 (n = 15) | 0.33 ± 0.04 (n = 15) | 3.78 ± 0.32 (n = 15) |
| Donor K280N Tn exch (N = 1) | 15.9 ± 1.9+ (n = 12) | 77 ± 9 (n = 10) | 1.04±0.08++ (n = 12) | 186 ± 9+ (n = 12) | 0.60 ± 0.07++ (n = 13) | 4.18 ± 0.62 (n = 13) |
Means ± SE; N, number of patients in the group; n, number of myofibrils; P0, maximal Ca2+-activated tension. For the statistics of the comparison between groups in the first four rows, see Supplemental materials; *, K280N parameters for which the statistical analysis shows a significant difference versus all control groups. For the statistics of the cTn exchange experiments (bottom six rows): +, P < 0.05; ++, P < 0.01 Student’s t test for unpaired observations (exchanged myofibrils vs. sham-treated unexchanged myofibrils).