| . | WTSV129 (12) . | FT-WT0 (8) . | FT-WT2 (8) . | FT-WT4 (8) . | FT-WT5 (8) . | FT-WT8 (8) . | FT-WT12 (8) . | FT-WT20 (8) . | cMyBP-C null (10) . |
|---|---|---|---|---|---|---|---|---|---|
| Body weight (g) | 29.2 ± 1.1 | 23.7 ± 1.5 | 24.5 ± 1.5 | 24.2 ± 1.2 | 24.6 ± 1.4 | 24.8 ± 1.4 | 25.1 ± 1.3 | 27.0 ± 1.4 | 23.2 ± 1.0 |
| Diet | Control | Control | Dox | Dox | Dox | Dox | Dox | Dox | Control |
| Time course | 0 wk | 2 wk | 4 wk | 4 wk | 4 wk | 4 wk | 4 wk | ||
| Diet | Control | Control | Control | Control | |||||
| Time course | 1 wk | 4 wk | 8 wk | 16 wk | |||||
| LV morphology | |||||||||
| LVIDd (mm) | 3.77 ± 0.05 | 3.95 ± 0.14 | 4.12 ± 0.13 | 4.38 ± 0.12 | 4.60 ± 0.13 | 4.41 ± 0.13 | 4.45 ± 0.20 | 4.14 ± 0.08 | 5.08 ± 0.13a |
| LVIDs (mm) | 2.49 ± 0.08 | 2.66 ± 0.16 | 2.83 ± 0.12 | 3.37 ± 0.13 | 3.66 ± 0.11 | 3.38 ± 0.16 | 3.45 ± 0.20 | 3.06 ± 0.13 | 4.25 ± 0.14a |
| LVPWd (mm) | 0.66 ± 0.06 | 0.76 ± 0.01 | 0.82 ± 0.02 | 0.85 ± 0.01 | 0.85 ± 0.01 | 0.90 ± 0.01 | 0.91 ± 0.03 | 0.96 ± 0.02 | 0.83 ± 0.03a |
| LVPWs (mm) | 1.18 ± 0.04 | 1.19 ± 0.03 | 1.24 ± 0.03 | 1.14 ± 0.03 | 1.09 ± 0.04 | 1.23 ± 0.05 | 1.21 ± 0.03 | 1.24 ± 0.05 | 1.14 ± 0.04 |
| LVAWd (mm) | 0.65 ± 0.02 | 0.76 ± 0.02 | 0.83 ± 0.02 | 0.86 ± 0.02 | 0.88 ± 0.01 | 0.91 ± 0.02 | 0.91 ± 0.02 | 0.96 ± 0.04 | 0.82 ± 0.03a |
| LVAWs (mm) | 1.10 ± 0.04 | 1.22 ± 0.04 | 1.35 ± 0.05 | 1.27 ± 0.06 | 1.26 ± 0.03 | 1.40 ± 0.04 | 1.34 ± 0.05 | 1.34 ± 0.05 | 1.09 ± 0.05 |
| LV volumed (μl) | 61.3 ± 2.0 | 64.3 ± 7.2 | 79.6 ± 5.5 | 88.7 ± 5.7 | 97.6 ± 6.4 | 95.0 ± 9.1 | 96.8 ± 10.1 | 76.3 ± 3.7 | 123.7 ± 7.5a |
| LV volumes (μl) | 20.8 ± 1.8 | 24.6 ± 4.3 | 35.5 ± 5.1 | 44.6 ± 5.5 | 51.9 ± 6.0 | 47.7 ± 5.5 | 50.7 ± 6.7 | 37.3 ± 3.7 | 81.7 ± 6.4a |
| LV mass (mg) | 89.3 ± 2.4 | 108.9 ± 6.2 | 135.2 ± 9.1 | 146.1 ± 5.4 | 160.0 ± 10.2 | 174.4 ± 11.4 | 170.8 ± 10.8 | 149.0 ± 10.4 | 180.7 ± 8.9a |
| LV/BW (mg/g) | 3.0 ± 0.1 | 4.4 ± 0.4 | 5.6 ± 0.3 | 6.1 ± 0.2 | 6.6 ± 0.4 | 7.1 ± 0.5 | 6.8 ± 0.3 | 5.6 ± 0.1 | 7.6 ± 0.3a |
| LV function | |||||||||
| EF (%) | 64.8 ± 1.8 | 63.2 ± 3.0 | 56.5 ± 3.2 | 47.6 ± 4.4a | 42.7 ± 1.4a | 49.0 ± 1.5a | 48.5 ± 3.3a | 52.1 ± 2.5 | 33.0 ± 3.8a |
| EnFS (%) | 33.6 ± 1.1 | 34.0 ± 2.1 | 29.5 ± 2.1 | 24.1 ± 2.5a | 21.0 ± 0.8a | 25.4 ± 0.9a | 24.6 ± 2.0a | 26.6 ± 1.5 | 16.0 ± 2.0a |
| IVRT (ms) | 20.9 ± 1.0 | 20.4 ± 1.1 | 23.5 ± 0.7 | 27.0 ± 0.6a | 27.5 ± 1.3a | 28.4 ± 2.0a | 26.0 ± 1.9a | 22.2 ± 1.3 | 30.5 ± 1.1a |
| ET (ms) | 43.7 ± 1.2 | 41.9 ± 1.4 | 40.6 ± 1.3 | 37.9 ± 0.6 | 34.1 ± 0.9a | 33.6 ± 1.4a | 35.9 ± 1.3a | 40.4 ± 1.4 | 33.5 ± 0.9a |
| Heart rate (bpm) | 466 ± 16 | 451 ± 16 | 446 ± 13 | 458 ± 22 | 459 ± 15 | 469 ± 12 | 475 ± 20 | 470 ± 20 | 461 ± 13 |
| . | WTSV129 (12) . | FT-WT0 (8) . | FT-WT2 (8) . | FT-WT4 (8) . | FT-WT5 (8) . | FT-WT8 (8) . | FT-WT12 (8) . | FT-WT20 (8) . | cMyBP-C null (10) . |
|---|---|---|---|---|---|---|---|---|---|
| Body weight (g) | 29.2 ± 1.1 | 23.7 ± 1.5 | 24.5 ± 1.5 | 24.2 ± 1.2 | 24.6 ± 1.4 | 24.8 ± 1.4 | 25.1 ± 1.3 | 27.0 ± 1.4 | 23.2 ± 1.0 |
| Diet | Control | Control | Dox | Dox | Dox | Dox | Dox | Dox | Control |
| Time course | 0 wk | 2 wk | 4 wk | 4 wk | 4 wk | 4 wk | 4 wk | ||
| Diet | Control | Control | Control | Control | |||||
| Time course | 1 wk | 4 wk | 8 wk | 16 wk | |||||
| LV morphology | |||||||||
| LVIDd (mm) | 3.77 ± 0.05 | 3.95 ± 0.14 | 4.12 ± 0.13 | 4.38 ± 0.12 | 4.60 ± 0.13 | 4.41 ± 0.13 | 4.45 ± 0.20 | 4.14 ± 0.08 | 5.08 ± 0.13a |
| LVIDs (mm) | 2.49 ± 0.08 | 2.66 ± 0.16 | 2.83 ± 0.12 | 3.37 ± 0.13 | 3.66 ± 0.11 | 3.38 ± 0.16 | 3.45 ± 0.20 | 3.06 ± 0.13 | 4.25 ± 0.14a |
| LVPWd (mm) | 0.66 ± 0.06 | 0.76 ± 0.01 | 0.82 ± 0.02 | 0.85 ± 0.01 | 0.85 ± 0.01 | 0.90 ± 0.01 | 0.91 ± 0.03 | 0.96 ± 0.02 | 0.83 ± 0.03a |
| LVPWs (mm) | 1.18 ± 0.04 | 1.19 ± 0.03 | 1.24 ± 0.03 | 1.14 ± 0.03 | 1.09 ± 0.04 | 1.23 ± 0.05 | 1.21 ± 0.03 | 1.24 ± 0.05 | 1.14 ± 0.04 |
| LVAWd (mm) | 0.65 ± 0.02 | 0.76 ± 0.02 | 0.83 ± 0.02 | 0.86 ± 0.02 | 0.88 ± 0.01 | 0.91 ± 0.02 | 0.91 ± 0.02 | 0.96 ± 0.04 | 0.82 ± 0.03a |
| LVAWs (mm) | 1.10 ± 0.04 | 1.22 ± 0.04 | 1.35 ± 0.05 | 1.27 ± 0.06 | 1.26 ± 0.03 | 1.40 ± 0.04 | 1.34 ± 0.05 | 1.34 ± 0.05 | 1.09 ± 0.05 |
| LV volumed (μl) | 61.3 ± 2.0 | 64.3 ± 7.2 | 79.6 ± 5.5 | 88.7 ± 5.7 | 97.6 ± 6.4 | 95.0 ± 9.1 | 96.8 ± 10.1 | 76.3 ± 3.7 | 123.7 ± 7.5a |
| LV volumes (μl) | 20.8 ± 1.8 | 24.6 ± 4.3 | 35.5 ± 5.1 | 44.6 ± 5.5 | 51.9 ± 6.0 | 47.7 ± 5.5 | 50.7 ± 6.7 | 37.3 ± 3.7 | 81.7 ± 6.4a |
| LV mass (mg) | 89.3 ± 2.4 | 108.9 ± 6.2 | 135.2 ± 9.1 | 146.1 ± 5.4 | 160.0 ± 10.2 | 174.4 ± 11.4 | 170.8 ± 10.8 | 149.0 ± 10.4 | 180.7 ± 8.9a |
| LV/BW (mg/g) | 3.0 ± 0.1 | 4.4 ± 0.4 | 5.6 ± 0.3 | 6.1 ± 0.2 | 6.6 ± 0.4 | 7.1 ± 0.5 | 6.8 ± 0.3 | 5.6 ± 0.1 | 7.6 ± 0.3a |
| LV function | |||||||||
| EF (%) | 64.8 ± 1.8 | 63.2 ± 3.0 | 56.5 ± 3.2 | 47.6 ± 4.4a | 42.7 ± 1.4a | 49.0 ± 1.5a | 48.5 ± 3.3a | 52.1 ± 2.5 | 33.0 ± 3.8a |
| EnFS (%) | 33.6 ± 1.1 | 34.0 ± 2.1 | 29.5 ± 2.1 | 24.1 ± 2.5a | 21.0 ± 0.8a | 25.4 ± 0.9a | 24.6 ± 2.0a | 26.6 ± 1.5 | 16.0 ± 2.0a |
| IVRT (ms) | 20.9 ± 1.0 | 20.4 ± 1.1 | 23.5 ± 0.7 | 27.0 ± 0.6a | 27.5 ± 1.3a | 28.4 ± 2.0a | 26.0 ± 1.9a | 22.2 ± 1.3 | 30.5 ± 1.1a |
| ET (ms) | 43.7 ± 1.2 | 41.9 ± 1.4 | 40.6 ± 1.3 | 37.9 ± 0.6 | 34.1 ± 0.9a | 33.6 ± 1.4a | 35.9 ± 1.3a | 40.4 ± 1.4 | 33.5 ± 0.9a |
| Heart rate (bpm) | 466 ± 16 | 451 ± 16 | 446 ± 13 | 458 ± 22 | 459 ± 15 | 469 ± 12 | 475 ± 20 | 470 ± 20 | 461 ± 13 |
All values are expressed as means ± SEM, with the number of mice listed in parentheses. LV mass was calculated as 1.053 × [(LVIDd + LVPWd + LVAWd)3 − (LVIDd)3]. Dox, doxycycline; EnFS, endocardial fractional shortening; LVID, left ventricular internal dimension; LVAW, left ventricular anterior wall.
Significantly different compared to noninduced FT-WT and WT mice (P < 0.05).