Table 5.
Figure 6 electrophysiological measurements segregated by sex
MeasureWTNaVβ4−/−FGF14−/−Double KO
M (n = 2)F (n = 7)M (n = 5)F (n = 4)M (n = 6)F (n = 3)M (n = 4)F (n = 4)
Itrans eliminated by TTX (%) 54 ± 0.51 44.9 ± 4.6 45.6 ± 3.7 42 ± 3.8 43.6 ± 3.6 51.3 ± 2.2 58.3 ± 5.1 42.1 ± 1.5 
Itransdecay τfast (ms) control 0.62 ± 0.04 0.58 ± 0.02 0.58 ± 0.02 0.63 ± 0.03 0.53 ± 0.02 0.50 ± 0.04 0.54 ± 0.02 0.53 ± 0.02 
Itransdecay τfast (ms) TTX 0.88 ± 0.06 0.67 ± 0.03 0.73 ± 0.05 0.77 ± 0.03 0.57 ± 0.02 0.70 ± 0.13 0.75 ± 0.11 0.61 ± 0.05 
Itransdecay τslow (ms) control 12.8 ± 2.2 17.8 ± 1.1 18.9 ± 1.2 20 ± 2.6 15.8 ± 1.4 13.1 ± 0.4 15.4 ± 1.1 12.7 ± 2 
Itransdecay τslow (ms) TTX 10.9 ± 3 13.4 ± 0.66 14.4 ± 0.96 15.2 ± 1.9 12.6 ± 1.7 8.45 ± 0.62 10.8 ± 1.5 9.94 ± 1.7 
Fast control (%) 94 ± 0.1 93.3 ± 0.66 94.5 ± 0.31 94.5 ± 0.38 95.4 ± 0.47 94.2 ± 0.7 94.8 ± 0.93 95.1 ± 0.47 
Fast TTX (%) 91.8 ± 0.65 94.7 ± 0.68 94.2 ± 1.2 95.2 ± 0.83 96.3 ± 0.64 93.3 ± 1.3 92.9 ± 1.8 96.4 ± 1.3 
Relative Irsg (%) Control 3.78 ± 1.2 6.76 ± 0.98 5.43 ± 0.48 5.57 ± 0.95 3.87 ± 0.51 4.6 ± 0.7 4.44 ± 0.96 3.77 ± 0.65 
Relative Irsg (%) TTX 3.08 ± 1.1 3.33 ± 0.16 3.53 ± 0.2 2.93 ± 0.36 2.28 ± 0.16 2.14 ± 0.24 2.63 ± 0.45 2.23 ± 0.19 
Proportion Irsg eliminated by TTX 0.63 ± 0.01 0.71 ± 0.03 0.64 ± 0.02 0.68 ± 0.04 0.66 ± 0.03 0.77 ± 0.03 0.75 ± 0.02 0.64 ± 0.04 
CV control 0.43 0.38 0.20 0.34 0.32 0.26 0.43 0.35 
CV TTX 0.49 0.13 0.13 0.25 0.17 0.19 0.34 0.17 
MeasureWTNaVβ4−/−FGF14−/−Double KO
M (n = 2)F (n = 7)M (n = 5)F (n = 4)M (n = 6)F (n = 3)M (n = 4)F (n = 4)
Itrans eliminated by TTX (%) 54 ± 0.51 44.9 ± 4.6 45.6 ± 3.7 42 ± 3.8 43.6 ± 3.6 51.3 ± 2.2 58.3 ± 5.1 42.1 ± 1.5 
Itransdecay τfast (ms) control 0.62 ± 0.04 0.58 ± 0.02 0.58 ± 0.02 0.63 ± 0.03 0.53 ± 0.02 0.50 ± 0.04 0.54 ± 0.02 0.53 ± 0.02 
Itransdecay τfast (ms) TTX 0.88 ± 0.06 0.67 ± 0.03 0.73 ± 0.05 0.77 ± 0.03 0.57 ± 0.02 0.70 ± 0.13 0.75 ± 0.11 0.61 ± 0.05 
Itransdecay τslow (ms) control 12.8 ± 2.2 17.8 ± 1.1 18.9 ± 1.2 20 ± 2.6 15.8 ± 1.4 13.1 ± 0.4 15.4 ± 1.1 12.7 ± 2 
Itransdecay τslow (ms) TTX 10.9 ± 3 13.4 ± 0.66 14.4 ± 0.96 15.2 ± 1.9 12.6 ± 1.7 8.45 ± 0.62 10.8 ± 1.5 9.94 ± 1.7 
Fast control (%) 94 ± 0.1 93.3 ± 0.66 94.5 ± 0.31 94.5 ± 0.38 95.4 ± 0.47 94.2 ± 0.7 94.8 ± 0.93 95.1 ± 0.47 
Fast TTX (%) 91.8 ± 0.65 94.7 ± 0.68 94.2 ± 1.2 95.2 ± 0.83 96.3 ± 0.64 93.3 ± 1.3 92.9 ± 1.8 96.4 ± 1.3 
Relative Irsg (%) Control 3.78 ± 1.2 6.76 ± 0.98 5.43 ± 0.48 5.57 ± 0.95 3.87 ± 0.51 4.6 ± 0.7 4.44 ± 0.96 3.77 ± 0.65 
Relative Irsg (%) TTX 3.08 ± 1.1 3.33 ± 0.16 3.53 ± 0.2 2.93 ± 0.36 2.28 ± 0.16 2.14 ± 0.24 2.63 ± 0.45 2.23 ± 0.19 
Proportion Irsg eliminated by TTX 0.63 ± 0.01 0.71 ± 0.03 0.64 ± 0.02 0.68 ± 0.04 0.66 ± 0.03 0.77 ± 0.03 0.75 ± 0.02 0.64 ± 0.04 
CV control 0.43 0.38 0.20 0.34 0.32 0.26 0.43 0.35 
CV TTX 0.49 0.13 0.13 0.25 0.17 0.19 0.34 0.17 
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