| Measure . | WT . | FGF14−/− . | Double KO . | |||
|---|---|---|---|---|---|---|
| M (n = 2) . | F (n = 8) . | M (n = 1) . | F (n = 8) . | M (n = 5) . | F (n = 3) . | |
| Gmax (nS) | 46.5 ± 10.6 | 98.3 ± 8.5 | 98.9 | 74.5 ± 9 | 44.2 ± 4.4 | 65.1 ± 9.2 |
| V1/2 activation (mV) | −38.2 ± 3.7 | −38.6 ± 1.9 | −33 | −41.2 ± 2.1 | −34.9 ± 3.1 | −35.1 ± 3.5 |
| k activation (mV) | 5.2 ± 1.9 | 6.16 ± 0.8 | 5.78 | 5.11 ± 0.55 | 6.54 ± 0.47 | 5.44 ± 0.38 |
| V1/2 inactivation (mV) | −60 ± 1.6 | −58.9 ± 1.6 | −56.2 | −62 ± 1.24 | −62.1 ± 0.77 | −61.5 ± 1.2 |
| k inactivation (mV) | 5.92 ± 0.29 | 5.82 ± 0.2 | 5.85 | 5.9 ± 0.1 | 6.37 ± 0.32 | 5.99 ± 0.06 |
| Irsg rise (ms) | 7.39 ± 1.5 | 8.11 ± 0.87 | 8.32 | 7.59 ± 1 | 5.08 ± 1.5 | 8.87 ± 0.62 |
| Irsg decay τ (ms) | 28.2 ± 8 | 26.5 ± 0.72 | 14.4 | 29.2 ± 2.7 | 19.6 ± 3.5 | 27.8 ± 1.7 |
| Relative rsg (%) | 3.34 ± 0.77 | 2.63 ± 0.17 | 1.41 | 1.57 ± 0.07 | 1.37 ± 0.31 | 1.25 ± 0.26 |
| Itransdecay τfast (ms) | 0.75 ± 0.06 | 0.70 ± 0.04 | 0.69 | 0.59 ± 0.03 | 0.85 ± 0.15 | 1.02 ± 0.25 |
| Itransdecay τslow (ms) | 6.96 ± 1.4 | 9.95 ± 1.2 | 6.98 | 6.51 ± 0.41 | 7.05 ± 1.6 | 7.52 ± 0.74 |
| τ recovery (−30 mV; ms) | 10.5 ± 0.97 | 11.1 ± 0.55 | ||||
| Maximum recovery (−30 mV; %) | 67.3 ± 3.1 | 52.3 ± 2.1 | ||||
| τfast recovery (+30 mV; ms) | 2.16 ± 0.34 | 2.28 ± 0.3 | ||||
| τslow recovery (+30 mV; ms) | 12.1 ± 1.2 | 12.4 ± 1.5 | ||||
| Maximum recovery (+30 mV; %) | 72.3 ± 2.8 | 59.6 ± 3.0 | ||||
| Measure . | WT . | FGF14−/− . | Double KO . | |||
|---|---|---|---|---|---|---|
| M (n = 2) . | F (n = 8) . | M (n = 1) . | F (n = 8) . | M (n = 5) . | F (n = 3) . | |
| Gmax (nS) | 46.5 ± 10.6 | 98.3 ± 8.5 | 98.9 | 74.5 ± 9 | 44.2 ± 4.4 | 65.1 ± 9.2 |
| V1/2 activation (mV) | −38.2 ± 3.7 | −38.6 ± 1.9 | −33 | −41.2 ± 2.1 | −34.9 ± 3.1 | −35.1 ± 3.5 |
| k activation (mV) | 5.2 ± 1.9 | 6.16 ± 0.8 | 5.78 | 5.11 ± 0.55 | 6.54 ± 0.47 | 5.44 ± 0.38 |
| V1/2 inactivation (mV) | −60 ± 1.6 | −58.9 ± 1.6 | −56.2 | −62 ± 1.24 | −62.1 ± 0.77 | −61.5 ± 1.2 |
| k inactivation (mV) | 5.92 ± 0.29 | 5.82 ± 0.2 | 5.85 | 5.9 ± 0.1 | 6.37 ± 0.32 | 5.99 ± 0.06 |
| Irsg rise (ms) | 7.39 ± 1.5 | 8.11 ± 0.87 | 8.32 | 7.59 ± 1 | 5.08 ± 1.5 | 8.87 ± 0.62 |
| Irsg decay τ (ms) | 28.2 ± 8 | 26.5 ± 0.72 | 14.4 | 29.2 ± 2.7 | 19.6 ± 3.5 | 27.8 ± 1.7 |
| Relative rsg (%) | 3.34 ± 0.77 | 2.63 ± 0.17 | 1.41 | 1.57 ± 0.07 | 1.37 ± 0.31 | 1.25 ± 0.26 |
| Itransdecay τfast (ms) | 0.75 ± 0.06 | 0.70 ± 0.04 | 0.69 | 0.59 ± 0.03 | 0.85 ± 0.15 | 1.02 ± 0.25 |
| Itransdecay τslow (ms) | 6.96 ± 1.4 | 9.95 ± 1.2 | 6.98 | 6.51 ± 0.41 | 7.05 ± 1.6 | 7.52 ± 0.74 |
| τ recovery (−30 mV; ms) | 10.5 ± 0.97 | 11.1 ± 0.55 | ||||
| Maximum recovery (−30 mV; %) | 67.3 ± 3.1 | 52.3 ± 2.1 | ||||
| τfast recovery (+30 mV; ms) | 2.16 ± 0.34 | 2.28 ± 0.3 | ||||
| τslow recovery (+30 mV; ms) | 12.1 ± 1.2 | 12.4 ± 1.5 | ||||
| Maximum recovery (+30 mV; %) | 72.3 ± 2.8 | 59.6 ± 3.0 | ||||