Table 2.
Developmental assays using TMEM16A inhibitors
ConditionUndeveloped (%)Developed (%)Polyspermic (%)n
Control (MR/3) 0 ± 0 100 ± 0 9 ± 4 
10 µM MONNA 7 ± 2 93 ± 2 56 ± 9 
1 µM Ani9 2 ± 2 98 ± 2 17 ± 5 
ConditionUndeveloped (%)Developed (%)Polyspermic (%)n
Control (MR/3) 0 ± 0 100 ± 0 9 ± 4 
10 µM MONNA 7 ± 2 93 ± 2 56 ± 9 
1 µM Ani9 2 ± 2 98 ± 2 17 ± 5 

Mean ± SEM values for each fertilization condition are shown. Of the embryos that developed cleavage furrows, embryos were categorized as monospermic or polyspermic based on cleavage furrow symmetry.

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