Table 3. Changes in NaChBac gating... | Rockefeller University Press

Table 3.

Changes in NaChBac gating parameters induced by 4 µM 4-fluoropropofol

NaChBac mutant	Activation		Inactivation
NaChBac mutant	ΔV_1/2	ΔZ	ΔV_1/2	ΔZ
	mV	e₀	mV	e₀
WT	−14.11 ± 1.87^§§§	0.24 ± 0.32	−10.96 ± 0.80^§§§	−0.78 ± 0.21
V40C	−14.33 ± 1.20^§§§	0.29 ± 0.35	−10.56 ± 1.51^§§	−0.28 ± 0.32
S129C	−6.76 ± 2.37^§	−0.17 ± 0.08	−3.73 ± 3.49*	0.20 ± 0.81
T189C	−15.77 ± 1.92^§§	0.80 ± 0.14^§	−8.61 ± 2.02^§	−0.78 ± 0.26
F227C	−6.58 ± 3.11	−0.26 ± 0.18	−17.30 ± 1.29^§§§	−4.80 ± 0.58^§§,***

NaChBac mutant	Activation		Inactivation
NaChBac mutant	ΔV_1/2	ΔZ	ΔV_1/2	ΔZ
	mV	e₀	mV	e₀
WT	−14.11 ± 1.87^§§§	0.24 ± 0.32	−10.96 ± 0.80^§§§	−0.78 ± 0.21
V40C	−14.33 ± 1.20^§§§	0.29 ± 0.35	−10.56 ± 1.51^§§	−0.28 ± 0.32
S129C	−6.76 ± 2.37^§	−0.17 ± 0.08	−3.73 ± 3.49*	0.20 ± 0.81
T189C	−15.77 ± 1.92^§§	0.80 ± 0.14^§	−8.61 ± 2.02^§	−0.78 ± 0.26
F227C	−6.58 ± 3.11	−0.26 ± 0.18	−17.30 ± 1.29^§§§	−4.80 ± 0.58^§§,***

Values are given as mean ± SEM (n = 4–13). Control versus 4-fluoropropofol for each mutant, evaluated by paired t test: ^§, P < 0.05; ^§§, P < 0.01; ^§§§, P < 0.001. Change induced by 4-fluoropropofol in NaChBac WT versus in each mutant, evaluated by one-way ANOVA with Bonferroni post hoc correction: *, P < 0.05; ***, P < 1E-4.

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