Table 2. Baseline gating parameters of... | Rockefeller University Press

Table 2.

Baseline gating parameters of NaChBac single-cysteine mutants

NaChBac mutant	Activation		Inactivation
NaChBac mutant	V_1/2	Z	V_1/2	Z
	mV	e₀	mV	e₀
WT	−33.93 ± 1.26	3.34 ± 0.19	−54.08 ± 0.53	6.73 ± 0.28
V40C	−28.15 ± 1.62	3.29 ± 0.38	−47.34 ± 1.96***	6.19 ± 0.32
S129C	−41.68 ± 2.64	1.66 ± 0.17*	−77.84 ± 0.65***	3.66 ± 0.33*
T189C	−40.48 ± 1.09	4.23 ± 0.82	−58.04 ± 1.22	7.01 ± 0.33
F227C	−32.56 ± 4.36	2.18 ± 0.21	−60.84 ± 1.73**	5.07 ± 0.57*

NaChBac mutant	Activation		Inactivation
NaChBac mutant	V_1/2	Z	V_1/2	Z
	mV	e₀	mV	e₀
WT	−33.93 ± 1.26	3.34 ± 0.19	−54.08 ± 0.53	6.73 ± 0.28
V40C	−28.15 ± 1.62	3.29 ± 0.38	−47.34 ± 1.96***	6.19 ± 0.32
S129C	−41.68 ± 2.64	1.66 ± 0.17*	−77.84 ± 0.65***	3.66 ± 0.33*
T189C	−40.48 ± 1.09	4.23 ± 0.82	−58.04 ± 1.22	7.01 ± 0.33
F227C	−32.56 ± 4.36	2.18 ± 0.21	−60.84 ± 1.73**	5.07 ± 0.57*

Values are given as mean ± SEM (n = 4–12). Gating parameters of NaChBac WT versus each mutant, evaluated by one-way ANOVA with Bonferroni post hoc correction: *, P < 0.05; **, P < 0.01; ***, P < 0.0001.

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