Table 1. Published cryo-EM structures of... | Rockefeller University Press

Table 1.

Published cryo-EM structures of K_ATP

Structure	Construct	Ligands	Resolution	PDB	EMDB	Reference
			Å
Inhibited	Hamster SUR1 (Q608K), mouse Kir6.2-GFP	Glibenclamide	5.6	5WUA	EMD-6689	Li et al., 2017
Inhibited	Hamster SUR1 (FLAG tag), rat Kir6.2	Glibenclamide, ATP	5.8	5TWV	EMD-8470	Martin et al., 2017b
Inhibited	Hamster SUR1 (FLAG tag), rat Kir6.2	Glibenclamide, ATP	3.63	6BAA	EMD-7073	Martin et al., 2017a
Closed, SUR activated (propeller)	Human SUR1–(Ser-Ala)₃–human Kir6.2 (concatenated)	ATP (ADP), Mg²⁺, diC₈ PIP₂	5.6	6C3P	EMD-7339	Lee et al., 2017
Closed, SUR activated (quatrefoil)	Human SUR1–(Ser-Ala)₃–human Kir6.2 (concatenated)	ATP (ADP), Mg²⁺, diC₈ PIP₂	3.9	6C3O	EMD-7338	Lee et al., 2017

Structure	Construct	Ligands	Resolution	PDB	EMDB	Reference
			Å
Inhibited	Hamster SUR1 (Q608K), mouse Kir6.2-GFP	Glibenclamide	5.6	5WUA	EMD-6689	Li et al., 2017
Inhibited	Hamster SUR1 (FLAG tag), rat Kir6.2	Glibenclamide, ATP	5.8	5TWV	EMD-8470	Martin et al., 2017b
Inhibited	Hamster SUR1 (FLAG tag), rat Kir6.2	Glibenclamide, ATP	3.63	6BAA	EMD-7073	Martin et al., 2017a
Closed, SUR activated (propeller)	Human SUR1–(Ser-Ala)₃–human Kir6.2 (concatenated)	ATP (ADP), Mg²⁺, diC₈ PIP₂	5.6	6C3P	EMD-7339	Lee et al., 2017
Closed, SUR activated (quatrefoil)	Human SUR1–(Ser-Ala)₃–human Kir6.2 (concatenated)	ATP (ADP), Mg²⁺, diC₈ PIP₂	3.9	6C3O	EMD-7338	Lee et al., 2017

EMDB, Electron Microscopy Data Bank.