Table 2.
Summary of electrophysiological parameters determined for the TTXr sodium channel NaV1.9 and TTXs sodium channel subtypes. The parameters were measured in DRGs isolated from NaV1.8-deficient mice in the presence of 1,500 nM TTX and in the ND7/23 and N1E-115 cell lines
CurrentPeak current (pA)Conductance (nS)Integrated peak area (pA)Time to peak (ms)
20°C37°C43°CFC20°C37°C43°CFC20°C37°C43°CFC20°C37°C43°CFC
NaV1.9 −1,388.7 ± 208.2 −6,844 ± 1,108.4 −5,828.9 ± 1,168.5 4.9, 4.2 24.5 ± 3.4 106.1 ± 17.1 105.2 ± 20.5 4.3, 4.3 9.4 ± 1.5 43.5 ± 6.7 30.5 ± 4.8 4.6, 3.2 34.6 ± 5.0 2.4 ± 0.3 1.1 ± 0.1 14.4, 31.5 
TTXs in ND7/23 −2,335.0 ± 302.0 −2,314.1 ± 344.0 −1,605.4 ± 151.0 1.0, 0.7 37.1 ± 5.1 37.6 ± 5.7 25.0 ± 5.0 1.0, 0.7 2.0 ± 0.2 0.6 ± 0.1 0.4 ± 0.1 0.3, 0.2 0.58 ± 0.03 0.24 ± 0.02 0.19 ± 0.01 2.4, 3.1 
TTXs in N1E−115 −3,210.0 ± 310.6 −3,776.0 ± 294.8 −2,350.0 ± 296.6 1.2, 0.7 46.9 ± 5.7 58.9 ± 6.5 30.1 ± 6.7 1.3, 0.6 4.4 ± 0.4 2.6 ± 0.2 1.5 ± 0.1 0.6, 0.3 0.79 ± 0.05 0.37 ± 0.03 0.30 ± 0.03 2.1, 2.6 
CurrentPeak current (pA)Conductance (nS)Integrated peak area (pA)Time to peak (ms)
20°C37°C43°CFC20°C37°C43°CFC20°C37°C43°CFC20°C37°C43°CFC
NaV1.9 −1,388.7 ± 208.2 −6,844 ± 1,108.4 −5,828.9 ± 1,168.5 4.9, 4.2 24.5 ± 3.4 106.1 ± 17.1 105.2 ± 20.5 4.3, 4.3 9.4 ± 1.5 43.5 ± 6.7 30.5 ± 4.8 4.6, 3.2 34.6 ± 5.0 2.4 ± 0.3 1.1 ± 0.1 14.4, 31.5 
TTXs in ND7/23 −2,335.0 ± 302.0 −2,314.1 ± 344.0 −1,605.4 ± 151.0 1.0, 0.7 37.1 ± 5.1 37.6 ± 5.7 25.0 ± 5.0 1.0, 0.7 2.0 ± 0.2 0.6 ± 0.1 0.4 ± 0.1 0.3, 0.2 0.58 ± 0.03 0.24 ± 0.02 0.19 ± 0.01 2.4, 3.1 
TTXs in N1E−115 −3,210.0 ± 310.6 −3,776.0 ± 294.8 −2,350.0 ± 296.6 1.2, 0.7 46.9 ± 5.7 58.9 ± 6.5 30.1 ± 6.7 1.3, 0.6 4.4 ± 0.4 2.6 ± 0.2 1.5 ± 0.1 0.6, 0.3 0.79 ± 0.05 0.37 ± 0.03 0.30 ± 0.03 2.1, 2.6 

All recordings were made with CsF in the pipette solution at 20°C, 37°C, and 43°C. FC, fold change comparing 37°C and 43°C with 20°C.

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