Table 1. Summary of electrophysiological... | Rockefeller University Press

Table 1.

Summary of electrophysiological parameters determined for TTXr sodium channels Na_V1.9 and Na_V1.8. Parameters were measured in DRGs isolated from Na_V1.8- or Na_V1.9-deficient mice in the presence of 500 nM TTX and at 10°C, 20°C, and 30°C

Channel	Peak current (pA)				Conductance (nS)				Integrated peak area (pA)				Inactivation time constant (ms)			Time to peak (ms)
Channel	10°C	20°C	30°C	FC	10°C	20°C	30°C	FC	10°C	20°C	30°C	FC	20°C	30°C	FC	10°C	20°C	30°C	FC
Na_V1.9		−585.8 ± 135.7	−2,342.8 ± 448.7	4.0		8.3 ± 1.2	31.5 ± 8.1	3.8		4.9 ± 1.3	22.0 ± 6.8	4.5	31.0 ± 9.1	8.0 ± 1.2	3.9	40.7 ± 11.2	12.2 ± 1.9	3.5 ± 0.5	3.3, 3.5
Na_V1.8	−2,120 ± 876.8	−4,444.3 ± 1,275.6	−7,147.6 ± 2,005.5	1.6	32.2 ± 13.7	68.6 ± 20.8	117.1 ± 35.8	1.7	9.7 ± 3.2	15.7 ± 4.9	13.8 ± 4.2	0.9	2.5 ± 0.3	0.9 ± 0.1	2.8	6.4 ± 0.3	2.9 ± 0.2	1.3 ± 0.1	2.2, 2.2

Channel	Peak current (pA)				Conductance (nS)				Integrated peak area (pA)				Inactivation time constant (ms)			Time to peak (ms)
Channel	10°C	20°C	30°C	FC	10°C	20°C	30°C	FC	10°C	20°C	30°C	FC	20°C	30°C	FC	10°C	20°C	30°C	FC
Na_V1.9		−585.8 ± 135.7	−2,342.8 ± 448.7	4.0		8.3 ± 1.2	31.5 ± 8.1	3.8		4.9 ± 1.3	22.0 ± 6.8	4.5	31.0 ± 9.1	8.0 ± 1.2	3.9	40.7 ± 11.2	12.2 ± 1.9	3.5 ± 0.5	3.3, 3.5
Na_V1.8	−2,120 ± 876.8	−4,444.3 ± 1,275.6	−7,147.6 ± 2,005.5	1.6	32.2 ± 13.7	68.6 ± 20.8	117.1 ± 35.8	1.7	9.7 ± 3.2	15.7 ± 4.9	13.8 ± 4.2	0.9	2.5 ± 0.3	0.9 ± 0.1	2.8	6.4 ± 0.3	2.9 ± 0.2	1.3 ± 0.1	2.2, 2.2

All recordings were made with CsCl in the pipette solution. FC, fold change comparing 30°C with 20°C.

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