Table 1. Effect of propofol on NaChBac... | Rockefeller University Press

Table 1.

Effect of propofol on NaChBac and NavMs gating parameters

	NaChBac WT			NaChBac T220A	NavMs
	2 µM	5 µM	10 µM	5 µM	5 µM
ΔV_1/2 of activation (mV)	−12.62 ± 0.93	−9.82 ± 1.82	−14.98 ± 1.17	−14.16 ± 0.93	−12.46 ± 1.55
ΔV_1/2 of inactivation (mV)	−9.33 ± 0.67	−7.02 ± 1.29	−11.51 ± 0.65	N/A	−13.54 ± 1.61

	NaChBac WT			NaChBac T220A	NavMs
	2 µM	5 µM	10 µM	5 µM	5 µM
ΔV_1/2 of activation (mV)	−12.62 ± 0.93	−9.82 ± 1.82	−14.98 ± 1.17	−14.16 ± 0.93	−12.46 ± 1.55
ΔV_1/2 of inactivation (mV)	−9.33 ± 0.67	−7.02 ± 1.29	−11.51 ± 0.65	N/A	−13.54 ± 1.61

Changes in the midpoints (V_1/2) of activation and inactivation are evident at all concentrations and in all channels tested, P < 0.001, by paired samples t test.

[ViewLarge]