Table 2. Kinetic effects of halothane on... | Rockefeller University Press

Table 2.

Kinetic effects of halothane on Ca²⁺ release in voltage-clamped muscle fibers.

Halothane (%)	WT					YS
Halothane (%)	t_0.5 (ms)	P-value	Ca²⁺ Flux (mM/s)	P-value	n	t_0.5 (ms)	P-value	Ca²⁺ Flux (mM/s)	P-value	n
0	6.46 ± 1.21		12.22 ± 3.00		12	24.42 ± 3.98		42.35 ± 4.47		13
0.2	49.3 ± 9.30	0.00951^{^a}	20.55 ±3.40	0.0949	5	58.0 ± 13.5	0.121	13.43 ± 1.47	0.0000272^{^b}	3
0.5	50.80 ± 4.81	0.000154^{^b}	25.07 ± 3.88	0.0238^{^c}	6	53.58 ± 9.17	0.0225^{^c}	13.64 ± 1.16	0.0000262^{^b}	6

Halothane (%)	WT					YS
Halothane (%)	t_0.5 (ms)	P-value	Ca²⁺ Flux (mM/s)	P-value	n	t_0.5 (ms)	P-value	Ca²⁺ Flux (mM/s)	P-value	n
0	6.46 ± 1.21		12.22 ± 3.00		12	24.42 ± 3.98		42.35 ± 4.47		13
0.2	49.3 ± 9.30	0.00951^{^a}	20.55 ±3.40	0.0949	5	58.0 ± 13.5	0.121	13.43 ± 1.47	0.0000272^{^b}	3
0.5	50.80 ± 4.81	0.000154^{^b}	25.07 ± 3.88	0.0238^{^c}	6	53.58 ± 9.17	0.0225^{^c}	13.64 ± 1.16	0.0000262^{^b}	6

Quantification of the relaxation time course of Ca²⁺ release after depolarization to −30 mV (the second response in the dual-pulse experiments of Fig. 6). The half time of relaxation was used for comparison. Ca²⁺ flux values were measured at the end of the depolarizing pulse. Errors, SEM; n, number of experiments. P-values refer to changes caused by halothane compared with measures before halothane application.

P < 0.01.

P < 0.001.

P < 0.05.

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