Table 4. Fractional CDI Construct F CDI... | Rockefeller University Press

Table 4.

Fractional CDI

Construct	F_CDI	P value versus +ex47	P value versus Δex47	P value versus Δex47 + CaM₁₂	P value versus Δex47-3A
Ca_v1.4 + ex47	−0.19 ± 0.03	—	<0.001^{^a}	—	—
Ca_v1.4Δex47	0.57 ± 0.03	—	—	—	—
Ca_v1.4Δex47 + CaM₁₂	0.37 ± 0.07	<0.001^{^a}	0.008^{^a}	—	—
Ca_v1.4Δex47 + CaM₃₄	0.22 ± 0.05	0.012^{^a}	<0.001^{^a}	0.171^{^a}	—
Ca_v1.4Δex47 + CaM₁₂₃₄	0.09 ± 0.05	0.530^{^a}	<0.001^{^a}	0.002^{^a}	—
Ca_v1.4Δex47-5A	−0.12 ± 0.07	0.840^{^a}	<0.001^{^a}	—	—
Ca_v1.4Δex47-3A	0.37 ± 0.13	0.004^{^a}	0.056^{^a}	—	—
Ca_v1.4Δex47-3A + CaM₃₄	0.06 ± 0.01	—	—	—	0.044^{^b}

Construct	F_CDI	P value versus +ex47	P value versus Δex47	P value versus Δex47 + CaM₁₂	P value versus Δex47-3A
Ca_v1.4 + ex47	−0.19 ± 0.03	—	<0.001^a	—	—
Ca_v1.4Δex47	0.57 ± 0.03	—	—	—	—
Ca_v1.4Δex47 + CaM₁₂	0.37 ± 0.07	<0.001^a	0.008^a	—	—
Ca_v1.4Δex47 + CaM₃₄	0.22 ± 0.05	0.012^a	<0.001^a	0.171^a	—
Ca_v1.4Δex47 + CaM₁₂₃₄	0.09 ± 0.05	0.530^a	<0.001^a	0.002^a	—
Ca_v1.4Δex47-5A	−0.12 ± 0.07	0.840^a	<0.001^a	—	—
Ca_v1.4Δex47-3A	0.37 ± 0.13	0.004^a	0.056^a	—	—
Ca_v1.4Δex47-3A + CaM₃₄	0.06 ± 0.01	—	—	—	0.044^b

F_CDI values (mean ± SEM) were determined as indicated in the “Methods” section with the exception that for Ca_v1.4Δex47 + CaM₁₂, F_CDI was measured at −10 mV to accommodate the positive shift in the tail-current voltage curves.

One-way ANOVA with Tukey’s multiple comparison test.

Student’s t test.

[ViewLarge]

Sharing Unavailable