Table 1. Parameters for... | Rockefeller University Press

Table 1.

Parameters for voltage-dependent activation and current density from I–V data

Construct	Peak current density (pA/pF)	P value	*V_h*	P value versus Ca_v1.4Δex47	k	P value
I_Ca
Ca_v1.4 + ex47	−8 ± 1.0	0.043	7 ± 0.7	<0.001	−9 ± 0.4	0.160
Ca_v1.4Δex47	−17 ± 1.0	—	−1 ± 1.3	—	−10 ± 0.2	—
Ca_v1.4Δex47 + CaM₁₂	−6 ± 0.83	0.018	6 ± 1.4	<0.001	−10 ± 0.2	0.600
Ca_v1.4Δex47 + CaM₃₄	−12 ± 1.0	0.386	−2 ± 1.4	0.629	−8 ± 0.3	0.005
I_Ba
Ca_v1.4 + ex47	−12 ± 3.3	0.958	−6 ± 1.0	<0.001	−8 ± 0.3	0.133
Ca_v1.4Δex47	−12 ± 2.3	—	−14 ± 1.1	—	−7 ± 0.2	—
Ca_v1.4Δex47 + CaM₁₂	−13 ± 2.5	0.230	−15 ± 1.1	0.728	−7 ± 1.5	0.448
Ca_v1.4Δex47 + CaM₃₄	−7 ± 1.3	0.714	−18 ± 1.9	0.946	−8 ± 1.8	0.042

Construct	Peak current density (pA/pF)	P value	*V_h*	P value versus Ca_v1.4Δex47	k	P value
I_Ca
Ca_v1.4 + ex47	−8 ± 1.0	0.043	7 ± 0.7	<0.001	−9 ± 0.4	0.160
Ca_v1.4Δex47	−17 ± 1.0	—	−1 ± 1.3	—	−10 ± 0.2	—
Ca_v1.4Δex47 + CaM₁₂	−6 ± 0.83	0.018	6 ± 1.4	<0.001	−10 ± 0.2	0.600
Ca_v1.4Δex47 + CaM₃₄	−12 ± 1.0	0.386	−2 ± 1.4	0.629	−8 ± 0.3	0.005
I_Ba
Ca_v1.4 + ex47	−12 ± 3.3	0.958	−6 ± 1.0	<0.001	−8 ± 0.3	0.133
Ca_v1.4Δex47	−12 ± 2.3	—	−14 ± 1.1	—	−7 ± 0.2	—
Ca_v1.4Δex47 + CaM₁₂	−13 ± 2.5	0.230	−15 ± 1.1	0.728	−7 ± 1.5	0.448
Ca_v1.4Δex47 + CaM₃₄	−7 ± 1.3	0.714	−18 ± 1.9	0.946	−8 ± 1.8	0.042

V_h and k values (mean ± SEM) were determined from Boltzmann fits of I–V data. Peak current density was defined as the maximum current amplitude normalized to the cell capacitance. P values indicate comparisons with Ca_v1.4Δex47 and were determined by Student’s t test.

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