Table 4. Spermine block rates in GluA2... | Rockefeller University Press

Table 4.

Spermine block rates in GluA2 receptors with auxiliary proteins

Receptor	Two-conductance permeant blocker model												n
	k_on			k_off			k_perm			k₁	k_1'	K_d(0mV)
	a (µM⁻¹s⁻¹)	b (mV)		c (s⁻¹)	d (mV)		e (s⁻¹)	f (mV)		k₁	k_1'	(µM)
GluA2	31	199		184	-20		23	19		4.55E+09	2.95E+07	3.3	7
SEM	6	94		44	1		9	2		1.93E+09	2.04E+07	0.5
GluA2-γ2	24	369		499	-13		131	16		1.67E+08	4.16E+07	15	4
SEM	8	223		147	1		25	2		1.64E+08	4.12E+07	4
GluA2 + CNIH-3	44	291		313	-19		53	15		2.10E+09	1.29E+06	4.5	5
SEM	16	139		81	3		29	2		1.98E+09	1.06E+06	0.9

Receptor	Two-conductance permeant blocker model												n
	k_on			k_off			k_perm			k₁	k_1'	K_d(0mV)
	a (µM⁻¹s⁻¹)	b (mV)		c (s⁻¹)	d (mV)		e (s⁻¹)	f (mV)		k₁	k_1'	(µM)
GluA2	31	199		184	-20		23	19		4.55E+09	2.95E+07	3.3	7
SEM	6	94		44	1		9	2		1.93E+09	2.04E+07	0.5
GluA2-γ2	24	369		499	-13		131	16		1.67E+08	4.16E+07	15	4
SEM	8	223		147	1		25	2		1.64E+08	4.12E+07	4
GluA2 + CNIH-3	44	291		313	-19		53	15		2.10E+09	1.29E+06	4.5	5
SEM	16	139		81	3		29	2		1.98E+09	1.06E+06	0.9

Block rate parameters were obtained by fitting the current relaxation after the voltage steps.