| Receptor . | Two-conductance permeant blocker model . | n . | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| kon . | . | koff . | . | kperm . | . | k1 . | k1' . | Kd(0mV) . | |||||
| a (µM−1s−1) . | b (mV) . | c (s−1) . | d (mV) . | e (s−1) . | f (mV) . | (µM) . | |||||||
| GluA2 | 31 | 199 | 184 | -20 | 23 | 19 | 4.55E+09 | 2.95E+07 | 3.3 | 7 | |||
| SEM | 6 | 94 | 44 | 1 | 9 | 2 | 1.93E+09 | 2.04E+07 | 0.5 | ||||
| GluA2-γ2 | 24 | 369 | 499 | -13 | 131 | 16 | 1.67E+08 | 4.16E+07 | 15 | 4 | |||
| SEM | 8 | 223 | 147 | 1 | 25 | 2 | 1.64E+08 | 4.12E+07 | 4 | ||||
| GluA2 + CNIH-3 | 44 | 291 | 313 | -19 | 53 | 15 | 2.10E+09 | 1.29E+06 | 4.5 | 5 | |||
| SEM | 16 | 139 | 81 | 3 | 29 | 2 | 1.98E+09 | 1.06E+06 | 0.9 | ||||
| Receptor . | Two-conductance permeant blocker model . | n . | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| kon . | . | koff . | . | kperm . | . | k1 . | k1' . | Kd(0mV) . | |||||
| a (µM−1s−1) . | b (mV) . | c (s−1) . | d (mV) . | e (s−1) . | f (mV) . | (µM) . | |||||||
| GluA2 | 31 | 199 | 184 | -20 | 23 | 19 | 4.55E+09 | 2.95E+07 | 3.3 | 7 | |||
| SEM | 6 | 94 | 44 | 1 | 9 | 2 | 1.93E+09 | 2.04E+07 | 0.5 | ||||
| GluA2-γ2 | 24 | 369 | 499 | -13 | 131 | 16 | 1.67E+08 | 4.16E+07 | 15 | 4 | |||
| SEM | 8 | 223 | 147 | 1 | 25 | 2 | 1.64E+08 | 4.12E+07 | 4 | ||||
| GluA2 + CNIH-3 | 44 | 291 | 313 | -19 | 53 | 15 | 2.10E+09 | 1.29E+06 | 4.5 | 5 | |||
| SEM | 16 | 139 | 81 | 3 | 29 | 2 | 1.98E+09 | 1.06E+06 | 0.9 | ||||
Block rate parameters were obtained by fitting the current relaxation after the voltage steps.