Table 2.
Equilibrium spermine block in GluA2 receptors
ReceptorKd(0mV)h (mV)/δ (1–θ)k (mV)n
MeanSEMMeanSEMMeanSEM
Permeant blocker model    h (mV)      
GluA2 3.7 0.4  −11.8 0.4  24 12 
Woodhull model    δ (1–θ)      
GluA2 3.7 0.5  0.48 0.02    12 
GluA2-γ2 41  0.61 0.03    19 
GluA2 + CNIH-3 11  0.48 0.04    12 
ReceptorKd(0mV)h (mV)/δ (1–θ)k (mV)n
MeanSEMMeanSEMMeanSEM
Permeant blocker model    h (mV)      
GluA2 3.7 0.4  −11.8 0.4  24 12 
Woodhull model    δ (1–θ)      
GluA2 3.7 0.5  0.48 0.02    12 
GluA2-γ2 41  0.61 0.03    19 
GluA2 + CNIH-3 11  0.48 0.04    12 

Dissociation constants were obtained by fitting the equilibrium GV relationships.

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