Table 1. Unitary properties and Ca 2... | Rockefeller University Press

Table 1.

Unitary properties and Ca²⁺ affinity of WT and single L273D channels derived from hexameric Orai1 concatemers

Channel	P_o	N	i_Na(fA)	i_Ca (fA)	Ca²⁺ affinity (K_1/2, µM)	Hill coefficient (n_H)
WT^{^a}^,^{^b}	0.76 ± 0.04	8,339 ± 1,725	−87 ± 7	−19 ± 2	16 ± 3	1.15 ± 0.02
1xL273D^{^a}	0.56 ± 0.08	730 ± 157	−254 ± 28	−53 ± 10	47 ± 8	0.73 ± 0.05
P value^{^c}	0.057	0.029	0.029	0.019	0.016	0.016

Channel	P_o	N	i_Na(fA)	i_Ca (fA)	Ca²⁺ affinity (K_1/2, µM)	Hill coefficient (n_H)
WT^{^a}^,^{^b}	0.76 ± 0.04	8,339 ± 1,725	−87 ± 7	−19 ± 2	16 ± 3	1.15 ± 0.02
1xL273D^{^a}	0.56 ± 0.08	730 ± 157	−254 ± 28	−53 ± 10	47 ± 8	0.73 ± 0.05
P value^{^c}	0.057	0.029	0.029	0.019	0.016	0.016

Mean values ± SEM n = 4 cells for WT, 4–5 cells for 1xL273D.

Channel properties measured at −100 mV.

Values reproduced from Yen et al. (2016).

P values determined by Mann-Whitney unpaired t test.