Table 3.
FCDF calculated from F96–100 for ICa and IBa from 100-Hz protocol
ConstructF96-100 for ICaF96-100 for IBaP-value, ICa vs. IBaaFCDFP-value vs. Cav2.1bP-value vs. Cav2.2ab
Cav2.2-CT2.1 1.09 ± 0.03 (15) 0.89 ± 0.03 (15) <0.001 0.20 ± 0.03 (15) 1.000  
Cav2.2-pCT2.1 1.07 ± 0.02 (13) 0.93 ± 0.02 (11) <0.001 0.14 ± 0.02 (13) 0.370  
Cav2.2-dCT2.1 0.90 ± 0.03 (8) 0.92 ± 0.02 (10) 0.914 0.02 ± 0.03 (8) <0.001  
Cav2.2-EF2.1 0.85 ± 0.03 (10) 0.88 ± 0.03 (10) 0.520 −0.03 ± 0.03 (10) <0.001  
Cav2.2-pre-IQ-IQ2.1 0.90 ± 0.03 (10) 0.92 ± 0.02 (12) 0.583 −0.02 ± 0.03 (10) <0.001  
Cav2.2-CBD2.1 0.99 ± 0.03 (10) 0.93 ± 0.02 (11) 0.149 0.06 ± 0.03 (10) 0.006  
Cav2.2-pre-IQ-IQ-CBD2.1 0.95 ± 0.02 (11) 0.95 ± 0.04 (6) 0.689 0.00 ± 0.02 (11) <0.001  
Cav2.2-EF&CBD2.1 0.89 ± 0.03 (12) 0.86 ± 0.02 (10) 0.508 0.03 ± 0.03 (12) 0.001  
Cav2.2-EF-pre-IQ-IQ2.1 1.07 ± 0.03 (18) 0.94 ± 0.03 (13) 0.004 0.13 ± 0.03 (18) 0.851  
Cav2.1-CT2.2 1.08 ± 0.04 (10) 1.08 ± 0.02 (5) 0.966 0.00 ± 0.04 (10)  1.000 
Cav2.1-pCT2.2 1.05 ± 0.02 (5) 1.01 ± 0.02 (7) 0.073 0.04 ± 0.02 (5)  1.000 
Cav2.1-dCT2.2 1.24 ± 0.03 (4) 1.02 ± 0.02 (3) 0.024 0.22 ± 0.03 (4)  0.054 
Cav2.1-EF2.2 1.08 ± 0.03 (4) 1.02 ± 0.02 (6) 0.257 0.06 ± 0.03 (4)  1.000 
Cav2.1-pre-IQ-IQ2.2 1.03 ± 0.01 (8) 1.03 ± 0.02 (6) 0.831 0.00 ± 0.02 (8)  1.000 
Cav2.1-CBD2.2 1.27 ± 0.02 (8) 1.04 ± 0.04 (10) <0.001 0.23 ± 0.02 (8)  0.005 
Cav2.1-EF-pre-IQ-IQ2.2 1.05 ± 0.01 (11) 1.06 ± 0.02 (11) 0.645 −0.01 ± 0.00 (11)  1.000 
ConstructF96-100 for ICaF96-100 for IBaP-value, ICa vs. IBaaFCDFP-value vs. Cav2.1bP-value vs. Cav2.2ab
Cav2.2-CT2.1 1.09 ± 0.03 (15) 0.89 ± 0.03 (15) <0.001 0.20 ± 0.03 (15) 1.000  
Cav2.2-pCT2.1 1.07 ± 0.02 (13) 0.93 ± 0.02 (11) <0.001 0.14 ± 0.02 (13) 0.370  
Cav2.2-dCT2.1 0.90 ± 0.03 (8) 0.92 ± 0.02 (10) 0.914 0.02 ± 0.03 (8) <0.001  
Cav2.2-EF2.1 0.85 ± 0.03 (10) 0.88 ± 0.03 (10) 0.520 −0.03 ± 0.03 (10) <0.001  
Cav2.2-pre-IQ-IQ2.1 0.90 ± 0.03 (10) 0.92 ± 0.02 (12) 0.583 −0.02 ± 0.03 (10) <0.001  
Cav2.2-CBD2.1 0.99 ± 0.03 (10) 0.93 ± 0.02 (11) 0.149 0.06 ± 0.03 (10) 0.006  
Cav2.2-pre-IQ-IQ-CBD2.1 0.95 ± 0.02 (11) 0.95 ± 0.04 (6) 0.689 0.00 ± 0.02 (11) <0.001  
Cav2.2-EF&CBD2.1 0.89 ± 0.03 (12) 0.86 ± 0.02 (10) 0.508 0.03 ± 0.03 (12) 0.001  
Cav2.2-EF-pre-IQ-IQ2.1 1.07 ± 0.03 (18) 0.94 ± 0.03 (13) 0.004 0.13 ± 0.03 (18) 0.851  
Cav2.1-CT2.2 1.08 ± 0.04 (10) 1.08 ± 0.02 (5) 0.966 0.00 ± 0.04 (10)  1.000 
Cav2.1-pCT2.2 1.05 ± 0.02 (5) 1.01 ± 0.02 (7) 0.073 0.04 ± 0.02 (5)  1.000 
Cav2.1-dCT2.2 1.24 ± 0.03 (4) 1.02 ± 0.02 (3) 0.024 0.22 ± 0.03 (4)  0.054 
Cav2.1-EF2.2 1.08 ± 0.03 (4) 1.02 ± 0.02 (6) 0.257 0.06 ± 0.03 (4)  1.000 
Cav2.1-pre-IQ-IQ2.2 1.03 ± 0.01 (8) 1.03 ± 0.02 (6) 0.831 0.00 ± 0.02 (8)  1.000 
Cav2.1-CBD2.2 1.27 ± 0.02 (8) 1.04 ± 0.04 (10) <0.001 0.23 ± 0.02 (8)  0.005 
Cav2.1-EF-pre-IQ-IQ2.2 1.05 ± 0.01 (11) 1.06 ± 0.02 (11) 0.645 −0.01 ± 0.00 (11)  1.000 

FCDF and F96-100 (mean ± SEM) were determined as indicated in the text. Number of cells in parentheses.

a

Determined by Student’s t test.

b

Determined by Kruskal–Wallis test and post-hoc Dunn's test.

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