Table 1.
Model parameters
Parameterk0 [ms−1]k1 [mV−1]
Model 1   
ka 21.066 ± 3.341 0.025607 ± 0.003094 
kd 4.9846 ± 0.7914 −0.041864 ± 0.003096 
ko 79.237 ± 26.85 0.012616 ± 0.007132 
kc 0.19986 ± 0.0667 −0.0042279 ± 0.006837 
koi 4,059.03 0.012616 
kci 75,377.9 −0.0042279 
kos 14,288.7 0.012616 
kcs 65,148.3 −0.0042279 
ki 0.0041372 ± 0.003587 0.0081037 ± 0.02083 
kr 0.025486 ± 0.006448 −0.035336 ± 0.005562 
kio 0.00037617 ± 0.000664 0.0081037 
kro 0.007445 ± 0.03127 −0.035336 
kis 0.0102506 ± 0.004418 0.0042311 ± 0.006932 
krs 3.1687 × 10−6 ± 1.455 × 10−6 −0.061102 ± 0.006231 
kiso 0.00045328 ± 0.00005917 0.0042311 
krso 0.00025328 ± 0.0004963 −0.061102 
a 1.8728 ± 0.2528  
b 7.0396 ± 0.8488  
Model 2   
ka 0.901 −0.079 
kd 0.055 −0.167 
ko 41.126 0.021 
kc 0.255 0.01 
Parameterk0 [ms−1]k1 [mV−1]
Model 1   
ka 21.066 ± 3.341 0.025607 ± 0.003094 
kd 4.9846 ± 0.7914 −0.041864 ± 0.003096 
ko 79.237 ± 26.85 0.012616 ± 0.007132 
kc 0.19986 ± 0.0667 −0.0042279 ± 0.006837 
koi 4,059.03 0.012616 
kci 75,377.9 −0.0042279 
kos 14,288.7 0.012616 
kcs 65,148.3 −0.0042279 
ki 0.0041372 ± 0.003587 0.0081037 ± 0.02083 
kr 0.025486 ± 0.006448 −0.035336 ± 0.005562 
kio 0.00037617 ± 0.000664 0.0081037 
kro 0.007445 ± 0.03127 −0.035336 
kis 0.0102506 ± 0.004418 0.0042311 ± 0.006932 
krs 3.1687 × 10−6 ± 1.455 × 10−6 −0.061102 ± 0.006231 
kiso 0.00045328 ± 0.00005917 0.0042311 
krso 0.00025328 ± 0.0004963 −0.061102 
a 1.8728 ± 0.2528  
b 7.0396 ± 0.8488  
Model 2   
ka 0.901 −0.079 
kd 0.055 −0.167 
ko 41.126 0.021 
kc 0.255 0.01 

The table contains the estimated parameters for Model 1 (Fig. 3 A) and Model 2 (Fig. 7 A), given as mean and SD. All rate constants have the form k=k 0 ×e k 1 ×V . The a and b values represent allosteric factors. SD values are not given for some of the Model 1 parameters, because those parameters were not estimated but calculated (see Materials and methods). SD values are not given for Model 2, which was truncated from Model 1 and adjusted to describe only a subset of the VC data. The voltage sensitivity factors k1 can take both positive and negative values and their SDs should be interpreted as absolute values on a scale of approximately −0.15 to +0.15 mV−1, typical of voltage-gated channels. In contrast, the SDs of the pre-exponential factors k0 and allosteric factors a and b should be interpreted as relative to the estimated mean.

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