Table 2. Fit parameters for activation... | Rockefeller University Press

Table 2.

Fit parameters for activation of concatenated channels used in the study in control conditions and at saturating retigabine concentrations

Construct	Control V_1/2 (mV)	Max shifted V_1/2 (mV)	Control k (mV)	Max shifted k (mV)	n
WWWW	−44 ± 3	−103 ± 3	9.4 ± 1.1	7.8 ± 0.4	5
WWWF	−43.8 ± 0.7	−101.0 ± 1.3	6.9 ± 0.1	9.2 ± 0.1	5
WWFF	−44.1 ± 0.7	−93 ± 1	6.9 ± 0.1	12.0 ± 0.6	5
WFFF	−43.4 ± 1.2	−91.9 ± 0.7	9.3 ± 0.5	11.1 ± 0.2	5
FFFF	−42.8 ± 0.9	−46.3 ± 1	8.4 ± 0.9	7.3 ± 0.7	5

Construct	Control V_1/2 (mV)	Max shifted V_1/2 (mV)	Control k (mV)	Max shifted k (mV)	n
WWWW	−44 ± 3	−103 ± 3	9.4 ± 1.1	7.8 ± 0.4	5
WWWF	−43.8 ± 0.7	−101.0 ± 1.3	6.9 ± 0.1	9.2 ± 0.1	5
WWFF	−44.1 ± 0.7	−93 ± 1	6.9 ± 0.1	12.0 ± 0.6	5
WFFF	−43.4 ± 1.2	−91.9 ± 0.7	9.3 ± 0.5	11.1 ± 0.2	5
FFFF	−42.8 ± 0.9	−46.3 ± 1	8.4 ± 0.9	7.3 ± 0.7	5

Conductance–voltage relationships were fit with the equation G/G_max = 1/(1 + e^−(V-V_1/2^)/k). Data are mean ± SEM.