Table 1. Double Boltzmann fit parameters... | Rockefeller University Press

Table 1.

Double Boltzmann fit parameters for KCNQ3* activation in a range of retigabine concentrations

RTG concentration (µM)	Shifted component, a	V_{1/2 a} (mV)	V_{1/2 b} (mV)	k_a	k_b	n
0	—	—	−41.8 ± 0.7	—	7.6 ± 0.2	5
1	0.12	−93.3 ± 0.7	−46.0 ± 1.1	5.9 ± 0.4	9.2 ± 0.3	5
3	0.32	−93.5 ± 0.3	−48.3 ± 1.2	6.9 ± 0.1	9.9 ± 0.6	5
10	0.72	−98.8 ± 0.7	−62.0 ± 1.7	7.6 ± 0.2	11.4 ± 0.5	5
30	1	−97.4 ± 2.4	—	9.4 ± 1.3	—	5
100	1	−103.3 ± 0.8	—	7.9 ± 0.7	—	5
300	1	−102.0 ± 1.5	—	9.2 ± 0.8	—	5

RTG concentration (µM)	Shifted component, a	V_{1/2 a} (mV)	V_{1/2 b} (mV)	k_a	k_b	n
0	—	—	−41.8 ± 0.7	—	7.6 ± 0.2	5
1	0.12	−93.3 ± 0.7	−46.0 ± 1.1	5.9 ± 0.4	9.2 ± 0.3	5
3	0.32	−93.5 ± 0.3	−48.3 ± 1.2	6.9 ± 0.1	9.9 ± 0.6	5
10	0.72	−98.8 ± 0.7	−62.0 ± 1.7	7.6 ± 0.2	11.4 ± 0.5	5
30	1	−97.4 ± 2.4	—	9.4 ± 1.3	—	5
100	1	−103.3 ± 0.8	—	7.9 ± 0.7	—	5
300	1	−102.0 ± 1.5	—	9.2 ± 0.8	—	5

Conductance–voltage relationships were fit with the equation G/G_max = a/(1 + e^−(V-V_1/2,a^)/k,a) + (1 − a)/(1 + e^−(V-V_1/2,b^)/k,b). Data presented are mean ± SEM.

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