Table 1.
Single-side monobody block
Monobodyτblockτopen[MB]koffkonKd
 s s  s−1 s−1M−1  
L3 WT 41 ± 3 77 ± 9 30 nM 0.025 4.3 × 105 58 ± 8 nM 
L3 E29Q 40 ± 7 19 ± 8 100 nM 0.025 5.4 × 105 25 ± 9 nM 
L3E79Q 0.13 ± 0.01 0.19 ± 0.03 12 μM 7.7 4.4 × 105 17.4 ± 0.8 μM 
Monobodyτblockτopen[MB]koffkonKd
 s s  s−1 s−1M−1  
L3 WT 41 ± 3 77 ± 9 30 nM 0.025 4.3 × 105 58 ± 8 nM 
L3 E29Q 40 ± 7 19 ± 8 100 nM 0.025 5.4 × 105 25 ± 9 nM 
L3E79Q 0.13 ± 0.01 0.19 ± 0.03 12 μM 7.7 4.4 × 105 17.4 ± 0.8 μM 
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