Table 1. Parameters of Boltzmann fit to... | Rockefeller University Press

Table 1.

Parameters of Boltzmann fit to G-V, SSI, and F-V curves for WT Na_V1.5 or VCF constructs expressed with or without WT β1 or β3

Parameter	DI	DI + β1	DI + β3	DII	DII + β1	DII + β3
G-V
V_1/2	−42.3 ± 1.7	−50.2 ± 1.0	−37.1 ± 1.8	−33.9 ± 2.2	−38.9 ± 3.0	−43.5 ± 2.2
k [n]	8.16 ± 0.7 [5]	8.3 ± 0.6 [4]	9.7 ± 0.5 [4]	9.5 ± 0.2 [4]	8.5 ± 1.2 [9]	−7.0 ± 0.5 [4]
SSI
V_1/2	−96.3 ± 4.55	−78.6 ± 2.1	−79.6 ± 2.4	−88.8 ± 1.3	−79.2 ± 4.5	−86.4 ± 0.7
k [n]	−11.0 ± 1.1 [4]	−6.4 ± 0.2 [8]	−7.0 ± 0.4 [4]	−8.2 ± 0.4 [4]	−6.5 ± 0.9 [7]	−6.1 ± 0.1 [4]
F-V
V_1/2	−111.5 ± 1.0	−92.1 ± 11.4	−75.7 ± 4.6	−48.4 ± 2.7	−51.1 ± 3.5	−45.5 ± 5.0
k [n]	21.3 ± 2.4 [4]	18.6 ± 2.3 [4]	15.3 ± 2.5 [4]	19.4 ± 0.7 [4]	23.1 ± 2.2 [6]	19.3 ± 0.8 [4]
	DIII	DIII + β1	DIII + β3	DIV	DIV + β1	DIV + β3
G-V
V_1/2	−43.7 ± 1.9	−40.0 ± 4.4	−39.2 ± 1.4	−36.8 ± 1.6	−34.6 ± 3.4	−38.2 ± 1.3
k [n]	7.8 ± 0.6 [5]	9.4 ± 0.7 [13]	7.4 ± 0.5 [6]	8.9 ± 0.9 [4]	9.2 ± 0.6 [19]	7.2 ± 0.5 [5]
SSI
V_1/2	−94.7 ± 1.9	−76.2 ± 2.5	−86.0 ± 1.6	−91.7 ± 3.4	−74.2 ± 3.1	−78.0 ± 1.6
k [n]	−9.8 ± 0.7 [4]	−6.7 ± 0.4 [7]	−7.6 ± 0.4 [4]	−12.6 ± 0.9 [5]	−10.3 ± 0.9 [13]	−9.2 ± 0.5 [5]
F-V
V_1/2	−120.7 ± 4.8	−122.1 ± 1.4	−98.0 ± 2.6	−88.2 ± 5.3	−56.8 ± 6.6	−63.2 ± 4
k [n]	25.6 ± 0.7 [4]	24.3 ± 1.3 [5]	26.4 ± 2.0 [5]	23.6 ± 3.1 [4]	14.5 ± 2.5 [6]	14.4 ± 0.3 [4]
	WT α	WT α + β1	WT α + β3
G-V
V_1/2	−35.8 ± 1.4	−34.6 ± 1.9	−30.4 ± 1.9
k [n]	6.8 ± 0.2 [4]	7.2 ± 0.7 [5]	7.4 ± 0.3 [3]
SSI
V_1/2	−84.8 ± 2.5	−74.0 ± 2.4	−75.2 ± 1.9
k [n]	−8.9 ± 0.7 [5]	−5.7 ± 0.3 [4]	−6.2 ± 0.3 [3]
	WT LFS α	WT LFS α + β1	WT LFS α + β3
Q-V
V_1/2	−60.7 ± 6.9	−49.8 ± 3.1	−55.1 ± 2.3
k [n]	25.9 ± 2.8 [4]	17.3 ± 1.2 [3]	17.3 ± 2.5 [8]

Parameter	DI	DI + β1	DI + β3	DII	DII + β1	DII + β3
G-V
V_1/2	−42.3 ± 1.7	−50.2 ± 1.0	−37.1 ± 1.8	−33.9 ± 2.2	−38.9 ± 3.0	−43.5 ± 2.2
k [n]	8.16 ± 0.7 [5]	8.3 ± 0.6 [4]	9.7 ± 0.5 [4]	9.5 ± 0.2 [4]	8.5 ± 1.2 [9]	−7.0 ± 0.5 [4]
SSI
V_1/2	−96.3 ± 4.55	−78.6 ± 2.1	−79.6 ± 2.4	−88.8 ± 1.3	−79.2 ± 4.5	−86.4 ± 0.7
k [n]	−11.0 ± 1.1 [4]	−6.4 ± 0.2 [8]	−7.0 ± 0.4 [4]	−8.2 ± 0.4 [4]	−6.5 ± 0.9 [7]	−6.1 ± 0.1 [4]
F-V
V_1/2	−111.5 ± 1.0	−92.1 ± 11.4	−75.7 ± 4.6	−48.4 ± 2.7	−51.1 ± 3.5	−45.5 ± 5.0
k [n]	21.3 ± 2.4 [4]	18.6 ± 2.3 [4]	15.3 ± 2.5 [4]	19.4 ± 0.7 [4]	23.1 ± 2.2 [6]	19.3 ± 0.8 [4]
	DIII	DIII + β1	DIII + β3	DIV	DIV + β1	DIV + β3
G-V
V_1/2	−43.7 ± 1.9	−40.0 ± 4.4	−39.2 ± 1.4	−36.8 ± 1.6	−34.6 ± 3.4	−38.2 ± 1.3
k [n]	7.8 ± 0.6 [5]	9.4 ± 0.7 [13]	7.4 ± 0.5 [6]	8.9 ± 0.9 [4]	9.2 ± 0.6 [19]	7.2 ± 0.5 [5]
SSI
V_1/2	−94.7 ± 1.9	−76.2 ± 2.5	−86.0 ± 1.6	−91.7 ± 3.4	−74.2 ± 3.1	−78.0 ± 1.6
k [n]	−9.8 ± 0.7 [4]	−6.7 ± 0.4 [7]	−7.6 ± 0.4 [4]	−12.6 ± 0.9 [5]	−10.3 ± 0.9 [13]	−9.2 ± 0.5 [5]
F-V
V_1/2	−120.7 ± 4.8	−122.1 ± 1.4	−98.0 ± 2.6	−88.2 ± 5.3	−56.8 ± 6.6	−63.2 ± 4
k [n]	25.6 ± 0.7 [4]	24.3 ± 1.3 [5]	26.4 ± 2.0 [5]	23.6 ± 3.1 [4]	14.5 ± 2.5 [6]	14.4 ± 0.3 [4]
	WT α	WT α + β1	WT α + β3
G-V
V_1/2	−35.8 ± 1.4	−34.6 ± 1.9	−30.4 ± 1.9
k [n]	6.8 ± 0.2 [4]	7.2 ± 0.7 [5]	7.4 ± 0.3 [3]
SSI
V_1/2	−84.8 ± 2.5	−74.0 ± 2.4	−75.2 ± 1.9
k [n]	−8.9 ± 0.7 [5]	−5.7 ± 0.3 [4]	−6.2 ± 0.3 [3]
	WT LFS α	WT LFS α + β1	WT LFS α + β3
Q-V
V_1/2	−60.7 ± 6.9	−49.8 ± 3.1	−55.1 ± 2.3
k [n]	25.9 ± 2.8 [4]	17.3 ± 1.2 [3]	17.3 ± 2.5 [8]

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