Table 4.
Comparing parameters of the transduction cascade derived from MEM and from fitting continuous noise spectra, as in Fig. 7 
ParameterUnitsNRForsk.
MEMNoise 1Noise 2MEMNoise 1Noise 2
Dark cGMP turnover rate Pd s−1 0.625 5.5 0.6  0.21 1.6 0.25 
Fast cytoplasmic Ca2+ turnover rate β s−1 3.2 0.45 6  2.2 0.25 2 
PDE subunit activity, turnovers per ROS volume â µM⋅s−1 4.7 × 10−4 1.45 × 10−5 4 × 10−5  4.7 × 10−4 1.65 × 10−5 6.8 × 10−5 
Rate of inactivation of spontaneously activated PDE kE s−1 - 1.9 7  - 4 4.75 
ParameterUnitsNRForsk.
MEMNoise 1Noise 2MEMNoise 1Noise 2
Dark cGMP turnover rate Pd s−1 0.625 5.5 0.6  0.21 1.6 0.25 
Fast cytoplasmic Ca2+ turnover rate β s−1 3.2 0.45 6  2.2 0.25 2 
PDE subunit activity, turnovers per ROS volume â µM⋅s−1 4.7 × 10−4 1.45 × 10−5 4 × 10−5  4.7 × 10−4 1.65 × 10−5 6.8 × 10−5 
Rate of inactivation of spontaneously activated PDE kE s−1 - 1.9 7  - 4 4.75 

Columns labeled Noise 1 refer to good-quality fits (curves 1 in Fig. 7, A and B), and those labeled Noise 2 refer to poor fits (curves 2 in Fig. 7, A and B).

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