Table 2.
Summary of some of the most used organelle-targeted indicators
GEIOrganelle targeted
PMNucleusER/SRGAMitochondriaAcidic compartmentsPeroxisomes
ATP:ADP Pellegatti et al., 2005  Imamura et al., 2009  Vishnu et al., 2014   Gajewski et al., 2003; Imamura et al., 2009; Nakano et al., 2011; Lefkimmiatis et al., 2013    
Calcium Marsault et al., 1997; Mao et al., 2008  Brini et al., 1993; Bengtson et al., 2010; Giacomello et al., 2010; Simonetti et al., 2013  Kendall et al., 1992; Palmer et al., 2004; Tang et al., 2011; Kipanyula et al., 2012; de la Fuente et al., 2013; Rodriguez-Garcia et al., 2014; Suzuki et al., 2014; Henderson et al., 2015; Rodríguez-Prados et al., 2015; Waldeck-Weiermair et al., 2015; Navas-Navarro et al., 2016  Pinton et al., 1998; Lissandron et al., 2010; Wong et al., 2013; Aulestia et al., 2015; Rodríguez-Prados et al., 2015  Rizzuto et al., 1992, 1994; Arnaudeau et al., 2001; Griesbeck et al., 2001; Nagai et al., 2001; Rapizzi et al., 2002; Filippin et al., 2003, 2005; Palmer et al., 2006; Giacomello et al., 2010; Park et al., 2010; Alam et al., 2012; Jean-Quartier et al., 2012; Loro et al., 2012; Akerboom et al., 2013  Mitchell et al., 2001; Shen et al., 2012; McCue et al., 2013; Albrecht et al., 2015; Ronco et al., 2015  Drago et al., 2008; Lasorsa et al., 2008  
cAMP DiPilato et al., 2004; Dyachok et al., 2006; Terrin et al., 2006  DiPilato et al., 2004    DiPilato et al., 2004; Terrin et al., 2006; Di Benedetto et al., 2013; Lefkimmiatis et al., 2013    
DG Sato et al., 2006   Sato et al., 2006  Sato et al., 2006  Sato et al., 2006    
ERK activity  Harvey et al., 2008       
Glucose  Fehr et al., 2004  Fehr et al., 2005      
Hydrogen Peroxide (H2O2 Malinouski et al., 2011  Merksamer et al., 2008   Belousov et al., 2006; Malinouski et al., 2011; Ermakova et al., 2014   Malinouski et al., 2011  
Phosphoinositides (PI3P2, PI3P3Sato, 2014  Ananthanarayanan et al., 2005  Sato, 2014  Sato, 2014  Sato, 2014    
InsP3  Sato et al., 2005; Kapoor et al., 2014       
Lactate  Barros et al., 2013       
Mg2+  Lindenburg et al., 2013b       
NADH-NAD+  Zhao et al., 2011    Hung et al., 2011; Zhao et al., 2011; Bilan et al., 2014    
pH Mukhtarov et al., 2013    Llopis et al., 1998; Miesenböck et al., 1998; Wu et al., 2000  Kneen et al., 1998; Llopis et al., 1998; Abad et al., 2004; Porcelli et al., 2005; Azarias and Chatton, 2011; Poburko et al., 2011; Tantama et al., 2011  Miesenböck et al., 1998; Ohara-Imaizumi et al., 2002; Zhu et al., 2009; Li and Tsien, 2012  Jankowski et al., 2001; Lasorsa et al., 2008  
PKA Allen and Zhang, 2006; Depry et al., 2011  Allen and Zhang, 2006  Liu et al., 2011   Allen and Zhang, 2006; Lefkimmiatis et al., 2013    
PKC Gallegos et al., 2006  Gallegos et al., 2006   Gallegos et al., 2006  Gallegos et al., 2006    
Redox state/ROS   van Lith et al., 2011   Hanson et al., 2004; Gutscher et al., 2008; Liu et al., 2012a; Albrecht et al., 2014   Yano et al., 2010  
Voltage Storace et al., 2016        
Zn2+   Qin et al., 2011  Qin et al., 2011  Dittmer et al., 2009; Miranda et al., 2012  Vinkenborg et al., 2009   
GEIOrganelle targeted
PMNucleusER/SRGAMitochondriaAcidic compartmentsPeroxisomes
ATP:ADP Pellegatti et al., 2005  Imamura et al., 2009  Vishnu et al., 2014   Gajewski et al., 2003; Imamura et al., 2009; Nakano et al., 2011; Lefkimmiatis et al., 2013    
Calcium Marsault et al., 1997; Mao et al., 2008  Brini et al., 1993; Bengtson et al., 2010; Giacomello et al., 2010; Simonetti et al., 2013  Kendall et al., 1992; Palmer et al., 2004; Tang et al., 2011; Kipanyula et al., 2012; de la Fuente et al., 2013; Rodriguez-Garcia et al., 2014; Suzuki et al., 2014; Henderson et al., 2015; Rodríguez-Prados et al., 2015; Waldeck-Weiermair et al., 2015; Navas-Navarro et al., 2016  Pinton et al., 1998; Lissandron et al., 2010; Wong et al., 2013; Aulestia et al., 2015; Rodríguez-Prados et al., 2015  Rizzuto et al., 1992, 1994; Arnaudeau et al., 2001; Griesbeck et al., 2001; Nagai et al., 2001; Rapizzi et al., 2002; Filippin et al., 2003, 2005; Palmer et al., 2006; Giacomello et al., 2010; Park et al., 2010; Alam et al., 2012; Jean-Quartier et al., 2012; Loro et al., 2012; Akerboom et al., 2013  Mitchell et al., 2001; Shen et al., 2012; McCue et al., 2013; Albrecht et al., 2015; Ronco et al., 2015  Drago et al., 2008; Lasorsa et al., 2008  
cAMP DiPilato et al., 2004; Dyachok et al., 2006; Terrin et al., 2006  DiPilato et al., 2004    DiPilato et al., 2004; Terrin et al., 2006; Di Benedetto et al., 2013; Lefkimmiatis et al., 2013    
DG Sato et al., 2006   Sato et al., 2006  Sato et al., 2006  Sato et al., 2006    
ERK activity  Harvey et al., 2008       
Glucose  Fehr et al., 2004  Fehr et al., 2005      
Hydrogen Peroxide (H2O2 Malinouski et al., 2011  Merksamer et al., 2008   Belousov et al., 2006; Malinouski et al., 2011; Ermakova et al., 2014   Malinouski et al., 2011  
Phosphoinositides (PI3P2, PI3P3Sato, 2014  Ananthanarayanan et al., 2005  Sato, 2014  Sato, 2014  Sato, 2014    
InsP3  Sato et al., 2005; Kapoor et al., 2014       
Lactate  Barros et al., 2013       
Mg2+  Lindenburg et al., 2013b       
NADH-NAD+  Zhao et al., 2011    Hung et al., 2011; Zhao et al., 2011; Bilan et al., 2014    
pH Mukhtarov et al., 2013    Llopis et al., 1998; Miesenböck et al., 1998; Wu et al., 2000  Kneen et al., 1998; Llopis et al., 1998; Abad et al., 2004; Porcelli et al., 2005; Azarias and Chatton, 2011; Poburko et al., 2011; Tantama et al., 2011  Miesenböck et al., 1998; Ohara-Imaizumi et al., 2002; Zhu et al., 2009; Li and Tsien, 2012  Jankowski et al., 2001; Lasorsa et al., 2008  
PKA Allen and Zhang, 2006; Depry et al., 2011  Allen and Zhang, 2006  Liu et al., 2011   Allen and Zhang, 2006; Lefkimmiatis et al., 2013    
PKC Gallegos et al., 2006  Gallegos et al., 2006   Gallegos et al., 2006  Gallegos et al., 2006    
Redox state/ROS   van Lith et al., 2011   Hanson et al., 2004; Gutscher et al., 2008; Liu et al., 2012a; Albrecht et al., 2014   Yano et al., 2010  
Voltage Storace et al., 2016        
Zn2+   Qin et al., 2011  Qin et al., 2011  Dittmer et al., 2009; Miranda et al., 2012  Vinkenborg et al., 2009   

References are provided for original works or reviews. For most of these sensors, the cytosolic forms are available and are not included in this table. Sensors for glutamate (Marvin et al., 2013), pyruvate (San Martín et al., 2014), G protein activation (van Unen et al., 2016), cGMP (Russwurm et al., 2007), and phosphate (Gu et al., 2006) are currently available only in the form localized in the cytosol.

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