Table 3. Activation and inactivation Na... | Rockefeller University Press

Table 3.

Activation and inactivation

Na_V1.5 channel (with control plasmid or CaM overexpression plasmid tested)	Activation				Inactivation
	V_1/2	k	n		V_1/2	k	n
	mV				mV
Na_V1.5^TTX-S/Con	−48.9 ± 1.3	2.1 ± 3.1	15		−79.3 ± 1.2	4.7 ± 0.4	14
/CaM	−50.8 ± 1.2	1.8 ± 3.6	15		−81.2 ± 1.6	4.5 ± 0.2	10
D1790G/pcNDA	−43.8 ± 1.1	5.1 ± 0.3	15		−94.1 ± 1.6^{^a}	5.1 ± 0.2	15
/CaM	−44.1 ± 1.5^{^a}	5.3 ± 0.5	13		−94.4 ± 1.5^{^a}	5.1 ± 0.2	14
Y1795C/Con	−54.2 ± 1.6	1.6 ± 2.9	16		−82.4 ± 1.4	4.9 ± 0.3	15
/CaM	−50.1 ± 1.7	2.5 ± 4.0	15		−81.5 ± 1.1	4.3 ± 0.1	15
E1901Q/Con	−51.6 ± 1.9	2.2 ± 0.3	16		−84.0 ± 2.2	4.7 ± 0.1	13
/CaM	−51.0 ± 2.2	2.4 ± 0.4	16		−83.0 ± 1.8	4.6 ± 0.2	15
Q1909R/Con	−52.2 ± 1.5	1.8 ± 0.4	14		−84.9 ± 1.9	4.9 ± 0.3	13
/CaM	−49.6 ± 1.6	2.5 ± 0.3	16		−84.3 ± 1.2	4.6 ± 0.2	13
R1913H/Con	−51.4 ± 1.4	1.7 ± 0.3	17		−79.0 ± 0.9	4.7 ± 0.1	15
/CaM	−49.4 ± 1.6	2.0 ± 0.4	15		−82.5 ± 0.7	5.0 ± 0.2	15
L1917K/Con	−46.2 ± 1.7	2.5 ± 0.3	13		−74.2 ± 1.0	4.3 ± 0.2	13
/CaM	−46.3 ± 1.6	2.2 ± 0.3	16		−77.2 ± 1.2	4.0 ± 0.1	16
ΔKPQ/Con	−42.5 ± 1.3^{^a}	5.3 ± 0.4	15		−88.1 ± 1.6^{^b}	4.6 ± 0.1	15
/CaM	−42.3 ± 1.9^{^a}	4.8 ± 0.4	15		−84.8 ± 1.3	4.7 ± 0.2	14

Na_V1.5 channel (with control plasmid or CaM overexpression plasmid tested)	Activation				Inactivation
	V_1/2	k	n		V_1/2	k	n
	mV				mV
Na_V1.5^TTX-S/Con	−48.9 ± 1.3	2.1 ± 3.1	15		−79.3 ± 1.2	4.7 ± 0.4	14
/CaM	−50.8 ± 1.2	1.8 ± 3.6	15		−81.2 ± 1.6	4.5 ± 0.2	10
D1790G/pcNDA	−43.8 ± 1.1	5.1 ± 0.3	15		−94.1 ± 1.6^{^a}	5.1 ± 0.2	15
/CaM	−44.1 ± 1.5^{^a}	5.3 ± 0.5	13		−94.4 ± 1.5^{^a}	5.1 ± 0.2	14
Y1795C/Con	−54.2 ± 1.6	1.6 ± 2.9	16		−82.4 ± 1.4	4.9 ± 0.3	15
/CaM	−50.1 ± 1.7	2.5 ± 4.0	15		−81.5 ± 1.1	4.3 ± 0.1	15
E1901Q/Con	−51.6 ± 1.9	2.2 ± 0.3	16		−84.0 ± 2.2	4.7 ± 0.1	13
/CaM	−51.0 ± 2.2	2.4 ± 0.4	16		−83.0 ± 1.8	4.6 ± 0.2	15
Q1909R/Con	−52.2 ± 1.5	1.8 ± 0.4	14		−84.9 ± 1.9	4.9 ± 0.3	13
/CaM	−49.6 ± 1.6	2.5 ± 0.3	16		−84.3 ± 1.2	4.6 ± 0.2	13
R1913H/Con	−51.4 ± 1.4	1.7 ± 0.3	17		−79.0 ± 0.9	4.7 ± 0.1	15
/CaM	−49.4 ± 1.6	2.0 ± 0.4	15		−82.5 ± 0.7	5.0 ± 0.2	15
L1917K/Con	−46.2 ± 1.7	2.5 ± 0.3	13		−74.2 ± 1.0	4.3 ± 0.2	13
/CaM	−46.3 ± 1.6	2.2 ± 0.3	16		−77.2 ± 1.2	4.0 ± 0.1	16
ΔKPQ/Con	−42.5 ± 1.3^{^a}	5.3 ± 0.4	15		−88.1 ± 1.6^{^b}	4.6 ± 0.1	15
/CaM	−42.3 ± 1.9^{^a}	4.8 ± 0.4	15		−84.8 ± 1.3	4.7 ± 0.2	14

P < 0.01 compared with Na_V1.5^TTX-S.

P < 0.05 compared with Na_V1.5^TTX-S.