Table 1.
Peak Na+ current density and persistent Na+ current
Na+ current testedConCaM
Peak current densityPersistent Na+ currentnPeak current densityPersistent Na+ currentn
 pApF % of peak   pApF % of peak  
NaV1.5TTX-S −210 ± 13       0.63 ± 0.08 35  −211 ± 16        0.54 ± 0.09 25 
D1790G −170 ± 22       0.76 ± 0.11 22  −180 ± 22        0.57 ± 0.09 17 
Y1795C −205 ± 21       1.74 ± 0.19a 18  −192 ± 12        0.48 ± 0.07 18 
E1901Q −175 ± 18       2.47 ± 0.53a 13  −176 ± 24        0.30 ± 0.07 13 
Q1909R −188 ± 21       1.40 ± 0.12a 15  −200 ± 28        0.50 ± 0.07 15 
R1913H −184 ± 16       1.51 ± 0.21a 15  −188 ± 20        0.50 ± 0.08 15 
L1917K −185 ± 21       0.27 ± 0.06 11  −175 ± 25        0.29 ± 0.06 11 
ΔKPQ −171 ± 19       1.90 ± 0.19a 14  −170 ± 27        1.95 ± 0.21a 14 
NaV1.2 WT −228 ± 37       0.66 ± 0.17 16  −193 ± 16        0.50 ± 0.13 16 
H1853R −204 ± 17       1.41 ± 0.20b 15  −181 ± 27        0.61 ± 0.13b 15 
R1918H −158 ± 27       3.17 ± 0.53b 20  −162 ± 27        0.80 ± 0.12b 20 
NaV1.6 WT −70 ± 4.7       13.20 ± 2.34 24  −79 ± 13        5.01 ± 0.92c 24 
NaV1.6TTX-R in Purkinje neurons −119 ± 16       6.96 ± 0.91 12  −130 ± 10        3.36 ± 0.45c 10 
Purkinje neurons −137 ± 13       9.03 ± 0.74 22  −132 ± 11        3.75 ± 0.54c 18 
Na+ current testedConCaM
Peak current densityPersistent Na+ currentnPeak current densityPersistent Na+ currentn
 pApF % of peak   pApF % of peak  
NaV1.5TTX-S −210 ± 13       0.63 ± 0.08 35  −211 ± 16        0.54 ± 0.09 25 
D1790G −170 ± 22       0.76 ± 0.11 22  −180 ± 22        0.57 ± 0.09 17 
Y1795C −205 ± 21       1.74 ± 0.19a 18  −192 ± 12        0.48 ± 0.07 18 
E1901Q −175 ± 18       2.47 ± 0.53a 13  −176 ± 24        0.30 ± 0.07 13 
Q1909R −188 ± 21       1.40 ± 0.12a 15  −200 ± 28        0.50 ± 0.07 15 
R1913H −184 ± 16       1.51 ± 0.21a 15  −188 ± 20        0.50 ± 0.08 15 
L1917K −185 ± 21       0.27 ± 0.06 11  −175 ± 25        0.29 ± 0.06 11 
ΔKPQ −171 ± 19       1.90 ± 0.19a 14  −170 ± 27        1.95 ± 0.21a 14 
NaV1.2 WT −228 ± 37       0.66 ± 0.17 16  −193 ± 16        0.50 ± 0.13 16 
H1853R −204 ± 17       1.41 ± 0.20b 15  −181 ± 27        0.61 ± 0.13b 15 
R1918H −158 ± 27       3.17 ± 0.53b 20  −162 ± 27        0.80 ± 0.12b 20 
NaV1.6 WT −70 ± 4.7       13.20 ± 2.34 24  −79 ± 13        5.01 ± 0.92c 24 
NaV1.6TTX-R in Purkinje neurons −119 ± 16       6.96 ± 0.91 12  −130 ± 10        3.36 ± 0.45c 10 
Purkinje neurons −137 ± 13       9.03 ± 0.74 22  −132 ± 11        3.75 ± 0.54c 18 
a

P < 0.01 compared with NaV1.5TTX-S.

b

P < 0.01 compared with NaV1.2.

c

P < 0.01 compared with Con.

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